| 纳米光学和生物单分子探测 |
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| 引用本文： | 白永强,刘丹,朱星.纳米光学和生物单分子探测[J].物理,2004,33(12):899-906. |
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| 作者姓名： | 白永强 刘丹 朱星 |
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| 作者单位： | 北京大学物理学院,人工微结构和介观物理国家重点实验室,北京,100871 |
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| 基金项目： | 国家自然科学基金(批准号:19890380-2)资助项目 |
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| 摘 要： | 纳米光学技术展示了纳米级探测本领，同时生物单分子探测所需要分辨尺度也是纳米数量级的，因此在生物单分子探测过程中，纳米光学发挥了巨大的作用．文章介绍了与生物单分子探测技术相关的纳米光学技术，包括量子近场光学探针技术、近场光学成像技术(包括扫描近场光学显微术及全内反射荧光显微术)和激光光钳测控技术及它们在生物单分子探测上的进展，从而在染色、成像、测控三个方面展示了纳米光学技术在生物方面的应用，并对其未来的发展方向进行了展望．
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| 关 键 词： | 纳米光学 单分子 全内反射 探测 近场光学 探针技术 测控 数量级 量子 分辨 |
Nanooptics and the detection of biological single molecules |
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| BAI Yong-Qiang LIU Dan ZHU XingSchool of Physics,Peking University,State Key Laboratory for Artificial Microstructure and Mesoscopic Physics,Beijing ,China.Nanooptics and the detection of biological single molecules[J].Physics,2004,33(12):899-906. |
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| Authors: | BAI Yong-Qiang LIU Dan ZHU XingSchool of Physics Peking University State Key Laboratory for Artificial Microstructure and Mesoscopic Physics Beijing China |
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| Institution: | BAI Yong-Qiang LIU Dan ZHU XingSchool of Physics,Peking University,State Key Laboratory for Artificial Microstructure and Mesoscopic Physics,Beijing 100871,China) |
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| Abstract: | Optics on the nanometer scale is particularly suitable for the detection of biological single molecules and may be expected to play a very significant role. Quantum near-field luminescent probe technology, near-field optics imaging technology (including scanning near-field optical microscopy and total internal reflection fluorescence microscopy) , and optical tweezers detection and control technology are reviewed. The application and prospects of nanooptics technology in probing, imaging, and detection and control of biological single molecules are discussed. |
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| Keywords: | nanooptics single molecule detection quantum dots scanning near-field optical microscopy total internal reflection fluorescence microscopy optical tweezers |
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