Stabilizer specific interaction of gold nanoparticles with a thermosensitive polymer hydrogel |
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Authors: | A Murugadoss Aslam Khan and Arun Chattopadhyay |
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Institution: | (1) Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, 781039, India;(2) Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati, 781039, India; |
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Abstract: | We report the experimental results on temperature-dependent studies of interactions between a novel biocompatible thermosensitive
polymer hydrogel and different stabilizing agent capped gold nanoparticles (Au NPs) with particle size ranging from 5 to 20 nm.
Stabilizing agents such as thioglycolic acid, tryptophan, and phenylalanine have been used as capping agents for Au NPs. The
poly-N-isopropyl acrylamide-co-acrylic acid (pNIPAm-AAc) with 3.0 ± 0.7 μm in size was synthesized by radical polymerization of
a selected mixture of N-isopropyl acrylamide (NIPAm), methylene-bis-acrylamide and acrylic acid (AAc). The capped Au NPs were mixed with a solution
of pNIPAm-AAc hydrogel. The temperature-dependent properties of the mixture were studied by UV–vis spectroscopy, dynamic light
scattering based particle size analysis, and transmission electron microscopy (TEM). The observations indicated change in
the lower critical solution temperature (LCST) depending on the nature of the stabilizer, with hydrophobic ones lowering the
value while hydrophilic stabilizers increasing the same. Also, the optical absorption due to Au NPs, when stabilized with
hydrophobic groups, reduced significantly at above LCST along with significant blue shift of wavelength maximum. |
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