Cell viability and MRI performance of highly efficient polyol-coated magnetic nanoparticles |
| |
| Authors: | Fernando Arteaga-Cardona Eric Gutiérrez-García Silvia Hidalgo-Tobón Ciro López-Vasquez Yazmín A Brito-Barrera Julia Flores-Tochihuitl Aracely Angulo-Molina Julio R Reyes-Leyva Roberto González-Rodríguez Jeffery L Coffer Umapada Pal Mario Pérez-Peña Diaz-Conti Diana Platas-Neri Pilar Dies-Suarez Rebeca Sosa Fonseca Oscar Arias-Carrión Miguel A Méndez-Rojas |
| |
| Institution: | 1.Departamento de Ciencias Químico-Biológicas,Universidad de las Américas de Puebla,San Andrés Cholula,Mexico;2.Universidad Autónoma del Estado de México,Instituto Literario,Toluca,Mexico;3.Departamento de Física,Universidad Autónoma Metropolitana,México City,Mexico;4.Hospital Infantil de México Federico Gómez,México City,Mexico;5.Facultad de Estomatología,Benemérita Universidad Autónoma de Puebla,Puebla,Mexico;6.Departamento de Ciencias Químico-Biológicas,Universidad de Sonora,Hermosillo,Mexico;7.Centro de Investigación Biomédica de Oriente (CIBIOR),Instituto Mexicano del Seguro Social,Metepec,Mexico;8.Department of Chemistry,Texas Christian University,Fort Worth,USA;9.Instituto de Física,Benemérita Universidad Autónoma de Puebla, Apdo,Puebla,Mexico;10.Escuela de Estudios Superiores del Jicarero,Universidad Autónoma del Estado de Morelos,Morelos,Mexico;11.Trastornos del Movimiento y Sue?o (TMS),Hospital General Dr. Manuel Gea González,México City,Mexico |
| |
| Abstract: | This work aimed at determining conditions that would allow us to control the size of the NPs and create a system with characteristics apt for biomedical applications. We describe a comprehensive study on the synthesis and physical characterization of two highly sensitive sets of triethylene glycol (TREG) and polyethylene glycol (PEG)-coated superparamagnetic iron oxide nanoparticles (SPIONs) to be evaluated for use as magnetic resonance (MR) contrast agents. The ferrofluids demonstrated excellent colloidal stability in deionized water at pH 7.0 as indicated by dynamic light scattering (DLS) data. The magnetic relaxivities, r 2, were measured on a 1.5 T clinical MRI instrument. Values in the range from 205 to 257 mM?1 s?1 were obtained, varying proportionally to the SPIONs’ sizes and coating nature. Further in vitro cell viability tests and in vivo biodistribution analyses of the intravenously administered nanoparticles showed that the prepared systems have good biocompatibility and migrate to several organs, mainly the meninges, spleen, and liver. Based on these results, our findings demonstrated the potential utility of these nanosystems as clinical contrast agents for MR imaging. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
