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Numerical study of the coupling between F0 with varied numbers of c-subunits and F1 in an ATP synthase
作者姓名:钱钧  谢平  窦硕星  王鹏业
作者单位:Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics,Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China;Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics,Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China;Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics,Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China;Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics,Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China
基金项目:Project supported by the National Natural Science Foundation of China (Grant Nos 60025516 and 10334100).
摘    要:ATP synthase is a rotary motor which is composed of two portions: the ‘rotor' Fo, consisting of a c-ring, and the ‘stator' F1, consisting of an a3/33 hexamer. In different species, the number of c-subunits which form the c-ring is varied from 10 to 14, whereas the a3/33 hexamer is fixed to be 3-fold symmetrical. We have numerically studied the rotational coupling between Fo with varied number of c-subunits and F1. It is found that, for any number of c-subunits, the rotor Fo advances 3 steps per revolution on average, which is determined by the period of F1, whereas the exact angular pausing positions are determined by the period of Fo. When the symmetry of the c-ring of Fo is matched with the 3-fold symmetry of F1, the three steps have equivalent sizes. If not matched, the three steps become nonequivalent: both the step size and average dwell time are different for these steps.

关 键 词:三磷酸腺甙化合酶  生物能量  数字模拟  旋转电机  回转轴  线粒体
收稿时间:2005-03-18
修稿时间:2005-03-182005-08-19

Numerical study of the coupling between F0 with varied numbers of c-subunits and F1 in an ATP synthase
Qian Jun,Xie Ping,Dou Shuo-Xing and Wang Peng-Ye.Numerical study of the coupling between F0 with varied numbers of c-subunits and F1 in an ATP synthase[J].Chinese Physics B,2005,14(11):2214-2221.
Authors:Qian Jun  Xie Ping  Dou Shuo-Xing and Wang Peng-Ye
Institution:Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics,Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China
Abstract:ATP synthase is a rotary motor which is composed of two portions: the `rotor' F0, consisting of a c-ring, and the `stator' F1, consisting of an \alpha3\beta3 hexamer. In different species, the number of c-subunits which form the c-ring is varied from 10 to 14, whereas the \alpha3 \beta3 hexamer is fixed to be 3-fold symmetrical. We have numerically studied the rotational coupling between F0 with varied number of c-subunits and F1. It is found that, for any number of c-subunits, the rotor F0 advances 3 steps per revolution on average, which is determined by the period of F1, whereas the exact angular pausing positions are determined by the period of F0. When the symmetry of the c-ring of F0 is matched with the 3-fold symmetry of F1, the three steps have equivalent sizes. If not matched, the three steps become nonequivalent: both the step size and average dwell time are different for these steps.
Keywords:ATP synthase  rotational coupling  numerical simulation
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