| 辐射诱导的DNA修复与细胞凋亡的ATP调控 |
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| 引用本文： | 周清明,张红,党秉荣,李文建,刘兵,闵凤玲,段昕,谢漪.辐射诱导的DNA修复与细胞凋亡的ATP调控[J].原子核物理评论,2005,22(2):225-228. |
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| 作者姓名： | 周清明 张红 党秉荣 李文建 刘兵 闵凤玲 段昕 谢漪 |
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| 作者单位： | 1. 中国科学院近代物理研究所,甘肃,兰州,730000;中国科学院研究生院,北京,100039
2. 中国科学院近代物理研究所,甘肃,兰州,730000 |
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| 基金项目： | 中国科学院百人计划基金资助项目~~ |
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| 摘 要： | 综述了DNA辐射损伤导致的细胞阻遏于G1期以及在该时期对DNA的修复活动，提出了较大剂量辐射诱导的三磷酸腺苷不足导致细胞凋亡的假说，并分析了细胞走向凋亡与修复的辨正关系。
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| 关 键 词： | p53 辐射 三磷酸腺苷 凋亡 |
| 文章编号： | 1007-4627(2005)02-0225-04 |
| 修稿时间： | 2004年9月6日 |
Regulation of ATP on DNA Repair and Cell Apoptosis Induced by Irradiation |
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| ZHOU Qing-ming,ZHANG Hong,DANG Bing-rong,LI Wen-jian,LIU Bing,MIN Feng-Ling,DUAN Xin,XIE Yi.Regulation of ATP on DNA Repair and Cell Apoptosis Induced by Irradiation[J].Nuclear Physics Review,2005,22(2):225-228. |
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| Authors: | ZHOU Qing-ming ZHANG Hong DANG Bing-rong LI Wen-jian LIU Bing MIN Feng-Ling DUAN Xin XIE Yi |
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| Institution: | ZHOU Qing-ming~ |
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| Abstract: | DNA damage induced by irradiation, which makes the cell arrested at G_(1 )stage and DNA repair being activated in this stage, are summarized. It is proposed that the deficiency of adenosine triphosphate which is induced by the larger irradiation dose, induces cell apoptosis. And the relationship of cell selecting repair and apoptosis is also analyzed. |
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| Keywords: | p53 irradiation adenosine triphosphate apoptosis |
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