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酵母β-葡聚糖对C离子辐射损伤小鼠免疫系统的防护作用
引用本文:王颖,陆栋,魏巍,荆西刚,王菊芳,李文建.酵母β-葡聚糖对C离子辐射损伤小鼠免疫系统的防护作用[J].原子核物理评论,2012,29(3):285-289.
作者姓名:王颖  陆栋  魏巍  荆西刚  王菊芳  李文建
作者单位:1.兰州大学, 甘肃 兰州 730000; 2.中国科学院近代物理研究所, 甘肃 兰州 730000
基金项目:中国科学院知识创新工程重要方向项目,甘肃省自然科学基金资助项目
摘    要:用12C6+离子束对小鼠进行一次性全身辐照, 检测不同剂量的酵母β-葡聚糖对12C6+辐射损伤小鼠免疫系统的防护作用。 辐照后观察小鼠的体重、 毛色及行为变化, 照后第2天和第7天检测小鼠外周血中白细胞含量, 照后第8天检测小鼠胸腺和脾脏内SOD, GSH PX活性和MDA含量。 实验结果表明, 给予酵母β 葡聚糖能减缓辐照引起的小鼠体重急剧下降, 增加小鼠外周血中白细胞含量,不同程度地恢复胸腺和脾脏SOD和GSH PX活性, 降低胸腺和脾脏MDA含量。 表明酵母β-葡聚糖对12C6+引起的小鼠辐射损伤具有防护作用。 To detect Yeast β-glucan’s protective effect on mice’s immune system after C ion beam radiation, mice were used as the test model. We observed the weight, hair color and behavior of mice everyday within a 7 d period of time after irradiation. Meanwhile, the content of white blood cell, on the 2nd and 7th day after irradiation was detected. We detected the thymus and spleen SOD, GSH PX activity and MDA content of the mice on the 8th day. The results showed that yeast β glucan could reduce the rapid weight loss of mice, increase white blood cell content, increase thymus and spleen SOD, GSH PX activity, decrease MDA content of thymus and spleen. These results indicate that yeast β glucan can protect mice’s immune system against C ion beam radiation damage.

关 键 词:酵母β-葡聚糖    12C6+离子    辐射防护
收稿时间:1900-01-01

Protective Effect of Yeast β-glucan on Immune System of Mice Irradiated by Carbon Ions
WANG Ying,LU Dong,WEI Wei,JING Xi-gang,WANG Ju-fang,LI Wen-jian.Protective Effect of Yeast β-glucan on Immune System of Mice Irradiated by Carbon Ions[J].Nuclear Physics Review,2012,29(3):285-289.
Authors:WANG Ying  LU Dong  WEI Wei  JING Xi-gang  WANG Ju-fang  LI Wen-jian
Institution:1.Lanzhou University, Lanzhou 730000, China;2.Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
Abstract:To detect Yeast β-glucan’s protective effect on mice’s immune system after C ion beam radiation, mice were used as the test model. We observed the weight, hair color and behavior of mice everyday within a 7 d period of time after irradiation. Meanwhile, the content of white blood cell, on the 2nd and 7th day after irradiation was detected. We detected the thymus and spleen SOD, GSH PX activity and MDA content of the mice on the 8th day. The results showed that yeast β glucan could reduce the rapid weight loss of mice, increase white blood cell content, increase thymus and spleen SOD, GSH PX activity, decrease MDA content of thymus and spleen. These results indicate that yeast β glucan can protect mice’s immune system against C ion beam radiation damage.
Keywords:Yeast β-glucan 12C6+ion radiation protection
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