| 重离子辐射哺乳动物细胞敏感性的分子机理 |
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| 引用本文： | 李文建,周光明,卫增泉,王菊芳,李强,党秉荣,颉红梅.重离子辐射哺乳动物细胞敏感性的分子机理[J].原子核物理评论,2003,20(1):42-47. |
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| 作者姓名： | 李文建 周光明 卫增泉 王菊芳 李强 党秉荣 颉红梅 |
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| 作者单位： | 中国科学院近代物理研究所 甘肃兰州730000; |
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| 基金项目： | 中国科学院西部之光资助项目(XB980604)，中国科学院院长特别支持基金资助项目(TB990601)~~ |
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| 摘 要： | 研究了用传能线密度125.5keV/μm的12C6+辐照小鼠黑色素瘤、中国仓鼠肺、人的宫颈癌、人的肝癌细胞的敏感性以及DNA双链断裂和DNA双链断裂片段分布,结果表明细胞敏感性与DNA双链断裂之间没有一致的关系,提出了细胞辐射敏感性的一种可能的分子机理,即DNA序列敏感性位点协同DNA双链断裂互补性机理.由此解释了4种细胞系的不同敏感性问题. Four types of cells, melanoma B16, cervical squamous carcinima HeLa, Chinese hamster V79 and hepatoma SMMC 7721, were irradiated by 125.5 keV/μm carbon ions. Celullar sensitivities to irradiation indicated by D50 , DNA double strand break (DSB) and distribution of DSB fragments expressed by molecular weight are studied. The results show that there is not a consistent relationship between cellular sensitivity and DNA DSB induction, a possible molecular mechanism of radiosensitivity which...
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| 关 键 词： | 重离子 哺乳动物细胞 辐射敏感性 分子机理 |
| 文章编号： | 1007-4627(2003)01-0042-06 |
| 收稿时间： | 1900-01-01 |
| 修稿时间： | 2002年9月17日 |
A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions |
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| Institution: | Institute of Modern Physics; Chinese Academy of Sciences; Lanzhou 730000; China ; |
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| Abstract: | Four types of cells, melanoma B16, cervical squamous carcinima HeLa, Chinese hamster V79 and hepatoma SMMC 7721, were irradiated by 125.5 keV/μm carbon ions. Celullar sensitivities to irradiation indicated by D50 , DNA double strand break (DSB) and distribution of DSB fragments expressed by molecular weight are studied. The results show that there is not a consistent relationship between cellular sensitivity and DNA DSB induction, a possible molecular mechanism of radiosensitivity which... |
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| Keywords: | heavy ion mammalian cell radiosensitivity mechanism |
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