120~430 MeV/u 碳离子的微剂量学特性研究(英文)

单粒子微剂量谱在放射治疗中是一个极其重要的参数，它可以用来评估辐射场的生物学效应。利用蒙特卡洛程序FLUKA模拟计算了由碳离子产生的混合辐射场能量沉积的微观模式。从已公开发表的文献中选取了实验测量300 MeV/u 碳离子的线能能谱，并与相同物理条件下模拟计算得到的线能能谱相比较，结果吻合得很好。此外，还计算了120~430 MeV/u 的碳离子的剂量平均线能能谱、频率平均线能和剂量平均线能。所得到的频率平均线能值为185~ 28.3 keV/m而剂量平均线能值则为272~ 64.1 keV/m。本文的结果对于制定碳离子放射治疗的治疗计划有着重要的意义.Microdosimetric single event spectrum is a significant parameter in radiotherapy, which can be used to evaluate the radiation biological effect. In this paper, microscopic patterns of energy deposition are simulated with Monte Carlo code FLUKA at mixed radiation fields during carbon ions therapy. The results are compared with experimental measured results at 300 MeV/u carbon ion and good agreement has been found. Meanwhile, dose-weighted lineal energy spectra, frequency averaged lineal energy values and dose averaged lineal energy values of carbon ion with energy from 120 to 430 MeV/u were calculated,too. The frequency averaged lineal energy values are from 185 to 28.3 keV/m while the dose averaged lineal energy values are from 272 to 64.1 keV/m. These studies are useful for treatment plan in carbon ion radiotherapy.

Study on Microdosimetric Characteristics of 120 to 430 MeV/u Carbon Ion

Microdosimetric single event spectrum is a significant parameter in radiotherapy, which can be used to evaluate the radiation biological effect. In this paper, microscopic patterns of energy deposition are simulated with Monte Carlo code FLUKA at mixed radiation fields during carbon ions therapy. The results are compared with experimental measured results at 300 MeV/u carbon ion and good agreement has been found. Meanwhile, dose-weighted lineal energy spectra, frequency averaged lineal energy values and dose averaged lineal energy values of carbon ion with energy from 120 to 430 MeV/u were calculated,too. The frequency averaged lineal energy values are from 185 to 28.3 keV/m while the dose averaged lineal energy values are from 272 to 64.1 keV/m. These studies are useful for treatment plan in carbon ion radiotherapy.