| 低剂量辐射诱导hepG2细胞克隆存活和细胞周期适应性反应 |
| |
| 引用本文： | 夏景光,李文建,王菊芳,郭传玲,魏巍,杨建设.低剂量辐射诱导hepG2细胞克隆存活和细胞周期适应性反应[J].原子核物理评论,2005,22(2):216-218. |
| |
| 作者姓名： | 夏景光 李文建 王菊芳 郭传玲 魏巍 杨建设 |
| |
| 作者单位： | 1 中国科学院近代物理研究所, 甘肃 兰州 730000;2 中国科学院研究生院, 北京 100039 |
| |
| 基金项目： | 国家自然科学基金资助项目(10335050)，国家重大基础研究专项资助项目(2003CCB00200)~~ |
| |
| 摘 要： | 以低剂量γ射线(0.05 Gy)预照射人肝癌细胞hep G2， 8 h后再用高剂量(3 Gy)照射， 测定了细胞的克隆存活率和细胞周期。 结果表明， 低剂量辐射预处理可诱导hep G2细胞产生克隆存活适应性反应， 并且有助于细胞通过G2/M期阻滞； 低剂量辐射诱导的克隆存活适应性反应与增强的通过细胞周期阻滞的能力之间有一定的相关性。 Human hepatoma cells hep G2 were irradiated with 3 Gy of γ ray 8 hours after primed with 0.05 Gy of γ ray， thereafter，cell survival and cell cycle were determined. The results indicated that both survival adaptive response and the enhanced ability to overcome G2/M arrest could be induced by pre irradiation with low dose of γ ray. It is suggested that there is a certain correlation between the survival adaptive response and the enhanced ability to overcome cell cycle arrest.
|
| 关 键 词： | 低剂量辐射 细胞周期阻滞 适应性反应 |
| 文章编号： | 1007-4627(2005)02-0216-03 |
| 收稿时间： | 1900-01-01 |
| 修稿时间： | 2004年9月1日 |
Adaptive Response for Survival and Cell Cycle Arrest Induced by Pre-irradiation with Low Dose of γ-ray to hep G2 Cells |
| |
| XIA Jing-Guang,LI Wen-jian,WANG Ju-Fang,GUO Chuan-Ling,WEI Wei,YANG Jian-She.Adaptive Response for Survival and Cell Cycle Arrest Induced by Pre-irradiation with Low Dose of γ-ray to hep G2 Cells[J].Nuclear Physics Review,2005,22(2):216-218. |
| |
| Authors: | XIA Jing-Guang LI Wen-jian WANG Ju-Fang GUO Chuan-Ling WEI Wei YANG Jian-She |
| |
| Institution: | 1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2 Graduate School of Chinese Academy of Sciences, Beijing 100039, China |
| |
| Abstract: | Human hepatoma cells hep G2 were irradiated with 3 Gy of γ ray 8 hours after primed with 0.05 Gy of γ ray， thereafter，cell survival and cell cycle were determined. The results indicated that both survival adaptive response and the enhanced ability to overcome G2/M arrest could be induced by pre irradiation with low dose of γ ray. It is suggested that there is a certain correlation between the survival adaptive response and the enhanced ability to overcome cell cycle arrest. |
| |
| Keywords: | low dose radiation cell cycle arrest adaptive response |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《原子核物理评论》浏览原始摘要信息 |
| 点击此处可从《原子核物理评论》下载免费的PDF全文 |
