| 多光子皮肤成像技术及其应用 |
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| 引用本文： | 应亚宸,张广杰,贾荟琳,陆政元,石玉洁,席鹏.多光子皮肤成像技术及其应用[J].中国光学,2019,12(1):104-111. |
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| 作者姓名： | 应亚宸 张广杰 贾荟琳 陆政元 石玉洁 席鹏 |
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| 作者单位： | 1. 北京大学 工学院 生物医学工程系, 北京 100871;
2. 北京大学 元培学院, 北京 100871 |
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| 基金项目： | 科技部重大仪器专项（No.2013YQ03065102）；国家自然科学基金（No.61475010，No.61729501）；科技部重点研发专项（No.SQ2017ZY040214） |
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| 摘 要： | 多光子成像技术是一种层析能力好、信噪比高的新型光学成像技术。在皮肤光学三维检测中,多光子技术已经应用于无创在体成像,且已得到产业化开发。本文将首先介绍多光子皮肤检测系统的若干核心技术,即双光子自发荧光技术、二次谐波成像技术、荧光寿命成像技术、相干反斯托克斯-拉曼成像技术等,然后简要介绍多光子成像系统在皮肤疾病成像检测上的应用,最后分析该系统的优势和未来可能的发展趋势。
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| 关 键 词： | 皮肤组织成像 多光子荧光成像 荧光寿命成像 相干反斯托克斯-拉曼 皮肤衰老检测 |
| 收稿时间： | 2018-02-26 |
Multi-photon skin tissue imaging technology and its applications |
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| YING Ya-chen,ZHANG Guang-jie,JIA Hui-lin,LU Zheng-yuan,SHI Yu-jie,XI Peng.Multi-photon skin tissue imaging technology and its applications[J].Chinese Optics,2019,12(1):104-111. |
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| Authors: | YING Ya-chen ZHANG Guang-jie JIA Hui-lin LU Zheng-yuan SHI Yu-jie XI Peng |
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| Institution: | 1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China;
2. Yuanpeng College, Peking University, Beijing 100871, China |
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| Abstract: | Multi-photon imaging is a new technique for optical imaging with inherent optical sectioning abilities and a high signal-to-noise ratio. Multi-photon microscopy has applications in dermatological imaging for its non-invasive and in situ imaging capability. As such, it has been applied commercially. In this paper, we first introduce the core technologies of multiphoton microscopy including two-photon auto-fluorescence imaging, second-harmonic generation(SHG), fluorescence life time imaging(FLIM) and coherent anti-Stokes Raman scattering(CARS). We then introduce its application on skin imaging analysis. Finally, we analyze the advantages and the possible future development of this technology. |
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| Keywords: | skin tissue imaging multi-photon fluorescence imaging fluorescence life time imaging coherent anti-stokes raman scattering skin aging detection |
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