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基于希尔伯特-黄变换的近红外脑功能成像信号分析
引用本文:周振宇,杨宏宇,龚辉,骆清铭,陆祖宏.基于希尔伯特-黄变换的近红外脑功能成像信号分析[J].光学学报,2007,27(2):07-312.
作者姓名:周振宇  杨宏宇  龚辉  骆清铭  陆祖宏
作者单位:1. 东南大学学习科学研究中心,南京,210096;东南大学生物科学与医学工程学院,南京,210096
2. 东南大学学习科学研究中心,南京,210096
3. 华中科技大学生物医学光子学教育部重点实验室,武汉,430074
基金项目:国家自然科学基金(30570655),东南大学预研基金(XJ0611237)资助课题
摘    要:近红外光谱技术(Near-infrared spectroscopy,NIRS)已被广泛应用于无损大脑功能检测,然而传统时频分析方法并不适用于非稳态、非线性的血氧信号。在视觉刺激实验中,采集被试前额叶的血氧信号,分别比较了傅里叶谱分析法、小波谱分析法和希尔伯特黄变换(Hilbert-Huang transform,HHT)方法在近红外脑功能成像信号分析中应用的结果。实验表明基于希尔伯特黄变换的谱分析方法优于其它两种方法,并且使近红外光谱研究可以采用事件相关设计的实验,为形成近红外光谱信号分析的标准方法开辟了新的途径。

关 键 词:医用光学与生物技术  近红外光成像  希尔伯特黄变换  谱分析
文章编号:0253-2239(2007)02-0307-6
收稿时间:2006/10/18
修稿时间:2006-10-18

Brain Signal Analysis of Functional Near-infrared Imaging Based on Hilbert-Huang Transform
Zhou Zhenyu,Yang Hongyu,Gong Hui,Luo Qingming,Lu Zuhong.Brain Signal Analysis of Functional Near-infrared Imaging Based on Hilbert-Huang Transform[J].Acta Optica Sinica,2007,27(2):07-312.
Authors:Zhou Zhenyu  Yang Hongyu  Gong Hui  Luo Qingming  Lu Zuhong
Institution:1 Research Centre of Learning Science, Southeast University, Nanjing 210096 ;2 School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096 ;3 Key Laboratory of Biomedical Photonics , Ministray of Education, Huazhong University of Science and Technology, Wuhan 430074
Abstract:Near-infrared spectroscopy(NIRS) has been widely used to access the brain functional activity non-invasively,but traditional signal analysis methods are unsuitable for non-linear and non-stationary data.A novel signal processing method is developed by using Hilbert-Huang transform (HHT) to perform spectral analysis of functional NIRS signals sampled in a vision stimulation experiment based on event-related design.Compared with wavelet based multi-resolution analysis(MRA) and Fourier spectral analysis,we demonstrate that the HHT method is better in the extraction of task related signal for observation of activation in the prefrontal cortex.This method indicates a new analytical tool for functional NIRS signals and enables us to understand the episode of functional NIRS more precisely.
Keywords:medical optics and biotechnology  near infrared imaging  Hilbert-Huang transform(HHT)  spectral analysis
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