Static magnetic fields aggravate the effects of ionizing radiation on cell cycle progression in bone marrow stem cells |
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| Authors: | Amir Sabet Sarvestani Parviz Abdolmaleki Seyed Javad Mowla Faezeh Ghanati Emran Heshmati Zeinab Tavasoli Azadeh Manoochehri Jahromi |
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| Institution: | 1. Department of Biophysics, Faculty of Bioscience, Tarbiat Modares University, Tehran, Iran;2. Department of Genetics, Faculty of Bioscience, Tarbiat Modares University, Tehran, Iran;3. Department of Plant Science, Faculty of Bioscience, Tarbiat Modares University, Tehran, Iran;4. Department of Midwifery, Islamic Azad University of Arsanjan, Arsanjan, Iran;1. Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, 14115-175, Iran;2. Department of Biology, Faculty of Science, Zanjan University, Zanjan, Iran;3. Life Science Group, Scientific Research Division, National Synchrotron Radiation Research Center, Taiwan;1. Department of Animal Science, Food Science and Animal Science Faculty, Ramin Agricultural and Natural Resources University, P.O. Box: 6341773637, Ahwaz, Iran .;2. Agricultural, Medical and Industrial Research School, Nuclear Science & Technology Research Institute, P.O. Box: 31485-498, Karaj, Iran;1. Department of Nutrigenomics and Bromatology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Jednosci 8, 41-200 Sosnowiec, Poland;2. Department of Molecular Biology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Jednosci 8, 41-200 Sosnowiec, Poland;3. Institute of Electrical Drives and Machines KOMEL, 188 Rozdzienskiego Street, 40-203 Katowice, Poland;4. Department of Medical Genetics, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Jednosci 8, 41-200 Sosnowiec, Poland |
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| Abstract: | In order to evaluate the influence of static magnetic fields (SMF) on the progression of cell cycle as a monitor of presumptive genotoxicity of these fields, the effects of a 15 mT SMF on cell cycle progression in rat bone marrow stem cells (BMSC) were examined. The cells were divided into two groups. One group encountered SMF alone for 5 h continuously but the other group exposed with X ray before treatment with SMF. The population of cells did not show any significant difference in the first group but the second group that was exposed with acute radiation before encountering SMF showed a significant increase in the number of cells in G2/M phase. So SMF has intensified the effects of X ray, where SMF alone, did not had any detectable influence on cell cycle.These findings suggest that magnetic fields (MF) play their role by increasing the effects of genotoxic agents and because of the greater concentration of free radicals in the presence of radical pair producers, this effect is better detectable. |
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