微泡对高强度聚焦超声焦域影响的研究

微泡对高强度聚焦超声(HIFU)治疗具有增效作用,而HIFU治疗中不同声学条件下微泡对HIFU治疗焦域的影响尚不清楚。本文基于声传播方程、Yang-Church气泡运动方程、生物热传导方程、时域有限差分法(FDTD)、龙格-库塔(RK)法数值仿真研究输入功率、激励频率和气泡初始半径对HIFU在含气泡体模中形成焦域的影响,并利用含Sono Vue造影剂的仿组织体模研究进行实验验证。结果表明,增大输入功率、气泡初始半径和升高激励频率均可增大焦域,随着输入功率的增大,焦域形状可能发生变化,而随着激励频率升高和气泡初始半径的增大,焦域会向远离换能器的方向移动。

The effect of microbubbles on high intensity focused ultrasound focal region

The synergistic effect of microbubbles was used to enhance HIFU treatment focal region. However, the effect of microbubbles on HIFU focal region in different acoustic conditions during HIFU therapy is not clear. In this paper, the effect of power, exciting frequency, and initial bubble radius on the HIFU focal region in tissue mimicing phantom with microbubbles was discussed based on the acoustic propagation equation, Yang-Church bubble motion equation, bio-heat transfer equation,the finite difference time domain (FDTD) method and Runge-Kutta (RK) method,and tested by experiments of tissue mimicing phantom with SonoVue microbubbles. The results show that,as the input power, initial bubble radius and exciting frequency increasing,the size of focal region increases. As the input power increasing ,the shape of focal region changes,as the initial bubble radius and the exciting frequency increasing, the focus moves away from the transducer side.