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人体肿瘤组织的拉曼光谱相关系数成像
引用本文:于舸,张攀,谭恩忠,张存洲.人体肿瘤组织的拉曼光谱相关系数成像[J].光谱学与光谱分析,2007,27(2):295-298.
作者姓名:于舸  张攀  谭恩忠  张存洲
作者单位:1. 北京石油化工学院数理系,北京,102617
2. 南开大学泰达应用物理学院,弱光非线性光子学材料先进技术及制备实验室,天津,300457
基金项目:北京市教委科技发展计划项目
摘    要:运用逐点扫描(Scanning)采谱技术,测量了人体乳腺肿瘤组织的阵列拉曼光谱集(Mapping);利用自编的软件,分析和计算了该谱集与参考谱DNA、细胞质等拉曼谱的相关系数;并将其映射为灰度值,构建了点阵的相关系数成像.结果表明,相关系数成像较好地反映了参考谱所代表的生化成分的分布;DNA谱与组织中其他成分谱的相关性很小,因此DNA谱的相关系数成像能够直接地反映成像区域DNA的分布,可信度尤其高.该研究结果为进一步研究乳腺肿瘤的拉曼诊断方法奠定了一定基础.

关 键 词:乳腺肿瘤  拉曼光谱  点扫描成像  相关系数  成像
文章编号:1000-0593(2007)02-0295-04
收稿时间:2005-11-07
修稿时间:2006-03-18

Study of Human Tumor Tissues by Raman Imaging Spectra
YU Ge,ZHANG Pan,TAN En-zhong,ZHANG Cun-zhou.Study of Human Tumor Tissues by Raman Imaging Spectra[J].Spectroscopy and Spectral Analysis,2007,27(2):295-298.
Authors:YU Ge  ZHANG Pan  TAN En-zhong  ZHANG Cun-zhou
Institution:1. Department of Mathematics and Physics, Beijing Institute of Petrochemical Technology, Beijing 102617, China 2. The Key Laboratory of Advanced Technique and Fabrication for Weak-Light Nonlinear Photonics Materials, Ministry of Education; TEDA Applied Physics College, Nankai University, Tianjin 300457, China
Abstract:The Raman mapping spectra were collected from the samples of fresh human breast tumor tissues with the excitation wavelength at 633 nm, their correlation coefficients with the reference spectra of chemical DNA, cytoplasm and extra-cellular matrix etc. were calculated, and the images were created based on these correlation coefficients. Examining these images, the authors found that they show approximately the distribution of the corresponding reference chemicals in human tissues and that the DNA spectrum correlation images reflect the DNA distribution quite well because of its much lower correlation with the spectra of other morphological chemicals. This work is helpful in understanding the chemical/morphological basis of the breast tissue Raman spectra and in developing the Raman diagnostic method for breast tumor.
Keywords:Breast tumor  Raman spectrum  Mapping  Correlation coefficients  Imaging
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