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| 色谱光谱法测试超临界压力下穿心莲内酯的结晶规律 | |
| 引用本文： | 张文成,张兴元,潘见.色谱光谱法测试超临界压力下穿心莲内酯的结晶规律[J].光谱学与光谱分析,2007,27(8):1657-1660. |
| 作者姓名： | 张文成 张兴元 潘见 |
| 作者单位： | 1. 合肥工业大学农产品生物化工教育部工程研究中心,安徽,合肥,230009;中国科学技术大学高分子科学与工程系,安徽,合肥,230026 2. 中国科学技术大学高分子科学与工程系,安徽,合肥,230026 3. 合肥工业大学农产品生物化工教育部工程研究中心,安徽,合肥,230009 |
| 基金项目： | 国家自然科学基金 , 教育部高校科技创新工程重大项目 |
| 摘 要： | 以30%和95%的穿心莲内酯为实验原料,采用超临界CO2萃取结晶法考察了不同压力下穿心莲内酯在结晶板上的分布规律,同时也考察了晶体的晶型和红外光谱的变化规律.研究证实:高效液相色谱分析,不同压力下穿心莲内酯在结晶板上都按纯度梯度结晶分布;X射线衍射分析,压力越高,晶体越趋于向比较单一的晶面上择优生长;红外光谱分析,压力的变化,并没有引起穿心莲内酯化学结构的改变. |
| 关 键 词： | 超临界CO2 萃取结晶 穿心莲内酯 高效液相色谱 X射线衍射 红外光谱 |
| 文章编号： | 1000-0593（2007）08-1657-04 |
| 修稿时间： | 2006-03-13 |
Test of the Effect of Different Supercritical Pressure on Andrographolide Crystallization with Chromatography and Spectrum |
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| ZHANG Wen-cheng,ZHANG Xing-yuan,PAN Jian.Test of the Effect of Different Supercritical Pressure on Andrographolide Crystallization with Chromatography and Spectrum[J].Spectroscopy and Spectral Analysis,2007,27(8):1657-1660. | |
| Authors: | ZHANG Wen-cheng ZHANG Xing-yuan PAN Jian |
| Institution: | 1. Engineering Research Center of Bio-Process of Ministry of Education, Hefei University of Technology, Hefei 230009, China 2. Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China |
| Abstract: | With the new technique of supercritical carbon dioxide extraction and crystallization,the experimental materials of 30% and 95% andrographolide were used to investigate the effect of different pressure on crystal distribution on crystallization board,what's more,the effect of X-ray diffraction and infrared ray spectrum on crystal was tested.The results showed that andrographolide was crystallized on crystallization board in purity gradient with high performance liquid chromatography;the higher the pressure,the higher the crystallization ratio.In addition,the crystal was inclining to directional growth;the chemical structure of andrographolide was not changed with the variety of pressure with infrared ray spectrum analysis. |
| Keywords: | Supercritical CO2 Extraction and crystallization Andrographolide High performance liquid chromatography X-ray diffraction Infrared ray spectrum |
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