| 血卟啉及金属血卟啉对嘌呤衍生物识别作用的研究 |
| |
| 引用本文： | 张勇,雷亚春,潘景浩,刘滇生.血卟啉及金属血卟啉对嘌呤衍生物识别作用的研究[J].光谱学与光谱分析,2004,24(10):1241-1243. |
| |
| 作者姓名： | 张勇 雷亚春 潘景浩 刘滇生 |
| |
| 作者单位： | 山西大学化学化工学院，山西大学现代化学所，山西 太原 030006 |
| |
| 基金项目： | 国家自然科学基金 (2 0 3750 2 4 )，山西省青年科技基金 (2 0 0 2 1 0 0 8)资助项目 |
| |
| 摘 要： | 采用紫外光谱法、荧光光谱法和核磁共振谱法研究了嘌呤与血卟啉及金属血卟啉的作用情况，并对影响因素(酸度和离子强度等)进行了试验。结果表明在pH 11.2 的Kolthoff缓冲溶液中，嘌呤有很强的荧光峰，且血卟啉及金属血卟啉对嘌呤有明显的识别作用，结合常数在104～105, 结合比均为1∶1。金属血卟啉的结合常数：KNi(Ⅱ)-HP＞KCo(Ⅱ)-HP＞KZn(Ⅱ)-HP＞KCu(Ⅱ)-HP，同时对识别机理进行了讨论，提出了两点和三点作用模式的识别机理。
|
| 关 键 词： | 血卟啉及金属血卟啉 嘌呤 识别 荧光光谱 紫外光谱 NMR |
| 文章编号： | 1000-0593(2004)10-1241-03 |
| 收稿时间： | 2004-02-18 |
| 修稿时间： | 2004年2月18日 |
Molecular Recognitions of Purines by Hematoporphyrin and Metalloporphyrin Receptors |
| |
| ZHANG Yong,LEI Ya-chun,PAN Jing-hao,LIU Dian-sheng.Molecular Recognitions of Purines by Hematoporphyrin and Metalloporphyrin Receptors[J].Spectroscopy and Spectral Analysis,2004,24(10):1241-1243. |
| |
| Authors: | ZHANG Yong LEI Ya-chun PAN Jing-hao LIU Dian-sheng |
| |
| Institution: | Department of Chemistry, Shanxi University, Taiyuan 030006, China |
| |
| Abstract: | The present paper studies the interactions of purines and porphyrin by fluorescence, UV, and NMR spectra. The optimal conditions (acidity and ion intensity) of the interaction of purines and hematoporphyrin and metalloporphyrin were investigated in detail. The result shows that hematoporphyrin and metalloporphyrin exhibit significant recognition of purines. The binding constants of metalloporphyrin: K(Ni(II)-HP) > K(Co(II)-HP) > K(Zn(II)-HP) > K(Cu(II)-HP) in pH 11.2 Kolthoff buffer solution. The mechanism of recognition was further discussed. Recognition is achieved by cooperative functions of three recognition groups (metalloporphyrin) and two recognition groups (hematoporphyrin). |
| |
| Keywords: | Hematoporphyrin and metalloporphyrin Purines Recognition Fluorescence UV NMR |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《光谱学与光谱分析》浏览原始摘要信息 |
| 点击此处可从《光谱学与光谱分析》下载免费的PDF全文 |
