20年前后正常人肺组织51种元素含量比较

采用电感耦合等离子体质谱仪(ICP-MS)、发射光谱仪(ICP-AES) 及石墨炉原子吸收光谱(GFAAS)对采自1982-83年及2004-05年的正常男性肺样品中的51种元素含量进行了测定及比较。样品经微波消解及敞开式酸法消解。结果显示，2004-05年样品相比于1982-83年样品，Na，Mg，P，K，As，Mo，Ag，Ba，Bi及除Sc外的所有被测稀土共23种元素的含量显著降低，Zn，Ga，Ge，Se，Au和Zr六种元素含量显著增加。这种变化可能与20年前后外界环境的改变及生活、饮食习惯等的改变有关，如20年前肺中稀土的高含量可能由于当时大量的稀土农用引起，而20年后某些微量有益元素(Zn和Se)明显上升与近年来健康意识提高有关，此外近年样品Pb, Cd, Cr和Ni等重金属元素含量的增加则有可能与空气质量恶化等因素有关。一半以上被测元素含量发生显著改变，故基于元素含量的正常值范围有必要在不同时期做出相应的调整。

Comparison of 51 Element Contents in Normal Human Lung Tissue over Twenty Years

Changes in content and distribution of elements in human tissues may reflect changes in environmental backgrounds,and are closely related to human health.To investigate the change in element background in normal lung tissue in different stage,we used ICP-MS,ICP-AES and GFAAS to determine 51 element contents in normal human lung samples of 1982-83 year(n=7) and compare with those of 2004-05 year(n=16).Samples were from healthy male adults who died suddenly,and were treated with microwave digestion and wet digestion method.The results show that the contents of 23 elements(Na,Mg,P,K,As,Mo,Ag,Ba,Bi,Y,La,Ce,Pr,Nd,Sm,Gd,Tb,Dy,Ho,Er,Tm,Yb and Lu) are significantly higher,and 6 elements(Zn,Ga,Ge,Se,Au and Zr) are significantly lower in the 2004-05 samples than those in the 1982-83 samples.This difference would be related to the changes in environmental backgrounds and people's living habit during twenty years.The distinctive decrease in contents of the 2004-05 samples for most measured rare earth elements(REEs) may be due to more rational usage of REEs in present,while were the soil and corps were largely abused in 1980s in China.The significant increase in contents of some useful micro-elements(Zn and Se) in the present samples maybe because of the increased intake of these elements as people own more health consciousness.Besides,the increased contents of heavy metal Pb,Cd,Cr and Ni in the present samples may be related to the deterioration of air quality as industrialization course.More than half of measured elements have been significantly changed over twenty years,indicating that some normal value ranges of element contents should be adjusted according to the difference.