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氯代5-氟脲嘧啶卟啉的红外光谱特性的研究
引用本文:何书美,刘彦钦,邱红,崔文艳.氯代5-氟脲嘧啶卟啉的红外光谱特性的研究[J].光谱学与光谱分析,2003,23(1):49-53.
作者姓名:何书美  刘彦钦  邱红  崔文艳
作者单位:1. 河北师范大学实验中心化学系,河北,石家庄,050016
2. 北京医药器械学校药学教研室,北京,100012
3. 河北科技大学环境工程系,河北,石家庄,050018
基金项目:河北省教委 ( 981 0 7)
摘    要:本文对新合成的对位及间位两类氯代苯基 5 氟脲嘧啶卟啉的红外光谱吸收峰进行了归属和总结 ,讨论了其红外吸收频率随取代基位置变化的规律。指出了苯环上的取代基为电负性强的基团时 ,由于场效应的存在 ,使被测化合物的羰基伸缩振动吸收峰的相对强度发生改变。同时 ,表明了嘧啶环上N原子发生了取代 ,形成单、双取代 5 氟脲嘧啶卟啉化合物的红外光谱特性。

关 键 词:氯代5-氟脲嘧啶卟啉  红外光谱  振动偶合  诱导效应
文章编号:1000-0593(2003)01-0049-05
修稿时间:2001年12月30

FTIR Studies of Chlorobenly-5-fluorouracil Porphyrin
HE Shu-mei,LIU Yan-qin,QIU Hong and CUI Wen-yan . Experiment Center and.FTIR Studies of Chlorobenly-5-fluorouracil Porphyrin[J].Spectroscopy and Spectral Analysis,2003,23(1):49-53.
Authors:HE Shu-mei  LIU Yan-qin  QIU Hong and CUI Wen-yan Experiment Center and
Institution:Experiment Center, Department of Chemistry, Hebei Normal University, Shijiazhuang 050016, China.
Abstract:In this paper new kind of porphyrin compounds was prepared, which combined well the affinity of prophyrin to malignant tumour with anticancer of 5-fluorouracil porphyrin. The IR spectra of m- and p-chlorophenyl-5-fluorouracil prophyrin were obtained and analyzed. The IR absorption peaks were investigated and concluded in detail. The IR absorption rule of chloropenly-5-fluorouracil prophyrin which occurred when m-substitution and p-substitution appeared respectively on phenyl, and single substitution of N1 and double substitution of N1 appeared respectively on phenyl or N1 and N1, N3 positions on pyrimidine ring was also discussed. The results show that the relative intensity of nu c-o stretching vibration changed obviously by field-effect when the substitution was strong electro-negative group. Meanwhile, the IR spectral characteristics of the compounds mentioned above were revealed, and this can be used to deduce the stereochemistry structure of them.
Keywords:Fluorouracil porphyrin  IR spectra  Characteristic absorption peak  Inductive effect  Coupling effect
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