丹参等11种中药金属元素含量测定及聚类分析研究

采用原子吸收分光光度法检测了丹参、枸杞子、党参、绞股蓝、冬虫夏草、黄芪、肉桂、细辛、龙胆草、山茱萸、杜仲共11种中药中钾、钙、镁、铁、锰、铜、锌和铬元素的含量, 运用模糊分类方法研究药物金属元素与药物疗效的相关性。结果显示，相关系数r=0.50时，有7种药物聚类相似;相关系数r=0.65时，有3种药物聚类相似;r=0.75时，有2种药物聚类相似。药物中金属元素含量丰富，相关系数较大的药物，其药物疗效相似性较大，揭示中药中微量元素与药物疗效密切相关。该研究为中药的质量评价提供一种新的方法，为研制新型的药物提供了有用的科学数据。

Study on the Determination and Blurred Classification of Metal Elements Content in Danshen etc 11 Kinds of Chinese Traditional Medicine

The contents of potassium, calcium, magnesium, iron, manganese, copper, zinc and chromium in 11 kinds of Chinese traditional medicines such as Danshen, Gouqizi, Dangshen, Jiaogulan, Dongchongxiacao, Huangqi, Rougui, Xixin, Longdancao, Shanzhuyu and Duzhong were determind by flame atomic absorption spectrophotometry, in order to study the interrelation between metal elements and the therapeutic effect through the method of blurred classification. The results showed that the cluster in 7 kinds of medicines was similar when the relative coefficent was 0. 50 ; cluster in 3 kinds of medicines was similar when the relative coefficent was 0. 65; the cluster in 2 kinds of medicines was similar when the relative coefficent was 0. 75. When the contents of metal elements are rich and the relative coefficient is considerably great, their therapeutic effect is similar. This suggests that trace elements have much to do with the therapeutic effect. The study provides new useful data for research on new types of medicines, and developing a new method for evaluating quality of Chinese tradition medicines.