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| 微波消解-ICP-MS法测定肺癌患者肺组织中33种元素 | |
| 引用本文： | 张霖琳,马千里,黄云超,吴国平,魏复盛.微波消解-ICP-MS法测定肺癌患者肺组织中33种元素[J].光谱学与光谱分析,2009,29(12). |
| 作者姓名： | 张霖琳 马千里 黄云超 吴国平 魏复盛 |
| 作者单位： | 1. 北京科技大学土木与环境工程学院,北京,100083 2. 昆明医学院第三附属医院,云南昆明,650031 3. 中国环境监测总站,北京,100012 |
| 基金项目： | 中美科技合作项目国家环保总局项目 |
| 摘 要： | 建立了冷冻干燥微波消解ICP-MS法测定肺癌患者肺组织中33种元素的方法.样品经真空冷冻干燥,采用纯化硝酸-过氧化氧体系微波消解,稀释定容后用ICP-MS对溶液进行元素的测定,在优化仪器工作参数后,以铑(Rh)和铼(Re)双内标进行校正.测定结果表明,元素榆出限为0.01～0.45 ng·mL~(-1),测定了国家标准物质GBw(E)080193牛肝中的元素,测定值与标准值或参考值一致,元素精密度(RSD)为2.1%～14.3%,回收率为90.1%～117.5%.用该法测定了6例肺癌患者的肿癌、痛旁和正常组织中33种元素的含量.所建立的方法快速、简便、准确,适于肺组织等生物样品中多种元素的测定. |
| 关 键 词： | 微波消解 电感耦合等离子体质谱 肺癌组织 元素 |
Determination of Thirty Three Elements in Lung Cancer Tissues of Patients with Lung Cancer by Microwave Digestion-ICP-MS |
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| ZHANG Lin-lin,MA Qian-li,HUANG Yun-chao,WU Guo-ping,WEI Fu-sheng.Determination of Thirty Three Elements in Lung Cancer Tissues of Patients with Lung Cancer by Microwave Digestion-ICP-MS[J].Spectroscopy and Spectral Analysis,2009,29(12). | |
| Authors: | ZHANG Lin-lin MA Qian-li HUANG Yun-chao WU Guo-ping WEI Fu-sheng |
| Institution: | ZHANG Lin-lin1,MA Qian-li2,HUANG Yun-chao2,WU Guo-ping3,WEI Fu-sheng3 1.The Civil and Environment Engineering School of University of Science & Technology Beijing,Beijing 100083,China2.The Third Affiliated Hospital of Kunming Medical College,Kunming 650031,China3.China National Environmental Monitoring Center,Beijing 100012,China |
| Abstract: | A method for determining 33 elements in lung tissues of patients with lung cancer was developed by using vacuum freeze-drying microwave digestion-ICP-MS.The lung tissue samples were treated by vacuum freeze-drying equipment.After microwave digestion in HNO3-H2O2 solution system,the samples were diluted with the method of constant volume.Under the optimized conditions the samples were analyzed by ICP-MS.The double internal standard elements Rh and Re were used to compensate for matrix suppression effect and ... |
| Keywords: | Microwave digestion ICP-MS Lung cancer tissue Elements |
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