TURBISCAN LAB稳定性分析仪研究农药WDG悬浮液稳定性

利用TURBISCAN LAB稳定性分析仪研究了农药WDG(水分散粒剂)悬浮液体系的稳定性。将自制苯乙烯磺酸/丙烯酸共聚物钠盐分散剂应用于75wt%的苯磺隆WDG配方中,通过测量苯磺隆WDG悬浮液的透射光和背散射光强度随时间的变化,可原位描述农药WDG悬浮液的动态沉降过程,反映农药WDG悬浮体系的稳定性。实验发现,当分散剂用量为6wt%,重均分子量为12000时,体系的悬浮稳定性较好。通过研究不同分子量及不同含量苯乙烯磺酸/丙烯酸共聚物钠盐分散剂的WDG悬浮液沉淀层厚度、颗粒沉降速率、悬浮体系颗粒粒径大小和粒径增大速率,有助于分析体系的不稳定性发生的机理,可方便有效地筛选剂型配方中的助剂及优化农药WDG的配方。

Study on the Stability of Pesticide WDG Suspension by TURBISCAN LAB

TURBISCAN LAB has been applied to analyze the stability of pesticide WDG(water dispersible granule)suspension.With the application of poly(styrene sulfonic acid-co-acrylic acid)sodium salt dispersant made by ourselves in a formula of 75 wt% tribenuron WDG,and by measuring the change in the intensity of transmission and backscattering light in pesticide WDG suspension with time,the dynamic sedimentation process of pesticide WDG suspension with time can be described in-situ,reflecting the stability of pesticide suspension system.It was found that when the contents of polymer dispersant were about 6 wt% in the WDG,and the average molecular weight was about 15 000,the stability of WDG suspension system was relatively good.Through studying the thickness of sedimentation,the settling rate of particles,the particle size,and the increasing rate of particle diameter in the suspension system in various kinds and contents of polymer dispersant,it has been made more convenient and efficient to sift the accessory ingredient in the formula of dosage form as well as to optimize the formula of pesticide WDG.