| 阿奇霉素含量的荷移光谱法测定 |
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| 引用本文： | 黄薇,刘雪静,赵凤林.阿奇霉素含量的荷移光谱法测定[J].光谱学与光谱分析,2006,26(5):913-916. |
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| 作者姓名： | 黄薇 刘雪静 赵凤林 |
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| 作者单位： | 1. 枣庄学院化学系,山东,枣庄,277100
2. 北京大学化学学院,北京,100871 |
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| 摘 要： | 用分光光度法分别研究了阿奇霉素与7,7,8,8-四氰基对二次甲基苯醌(TCNQ)和氯冉酸(CL)之间的荷移反应.实验表明:阿奇霉素与TCNQ间的反应在丙酮介质中进行,形成的络合物在743和842 nm有两个吸收峰,表观摩尔吸光系数分别是2.7×104L·mol-1·cm-1和5.0×104L·mol-1·cm-1;阿奇霉素与氯冉酸的反应在丙酮介质中进行,形成的络合物在530 nm处有吸收峰,表观摩尔吸光系数2.4×103 L·mol-1·cm-1.用摩尔比法和等摩尔连续变化法测得荷移络合物中阿奇霉素与配体的摩尔比均为1:2.用以上两种方法测定了阿奇霉素片剂中阿奇霉素的含量,相对标准偏差为1.0%～1.4%(n=6),回收率为97%以上,与标准方法比较结果准确.
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| 关 键 词： | 阿奇霉素 7 7 8 8-四氰基对二次甲基苯醌 氯冉酸 荷移反应 分光光度法 |
| 文章编号： | 1000-0593（2006）05-0913-04 |
| 收稿时间： | 2004-12-17 |
| 修稿时间： | 2005-05-04 |
Spectrophotometric Determination of Azithromycinbase by Charge Transfer Reaction |
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| HUANG Wei,LIU Xue-jing,ZHAO Feng-lin.Spectrophotometric Determination of Azithromycinbase by Charge Transfer Reaction[J].Spectroscopy and Spectral Analysis,2006,26(5):913-916. |
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| Authors: | HUANG Wei LIU Xue-jing ZHAO Feng-lin |
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| Institution: | Zaozhuang College, Zaozhuang 277100, China. |
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| Abstract: | The charge transfer interactions of Azithromycin and 7,7,8,8-tetracyanoquinodimethane (TCNQ) or chloranilic acid (CL) were investigated by spectrophotometry. The apparent molar absorptivity of TCNQ complex is 2.7 x 10(4) L x mol(-1) x cm(-1) at 743 nm, and 5.0 x 10(4) L x mol(-1) x cm(-1) at 842 nm; and that of CL complex is 2.4 x 10(3) L x mol(-1) x cm(-1). Beers law is obeyed in the concentration range of 0-30 mg x L(-1) for TCNQ method, and 5-225 mg x L(-1) for CL method. The relative standard deviations of the two methods are 1.0% and 1.4% (n = 6), respectively. The composition of complex of Azithromycin with 7,7,8,8-tetracyanoquinodimethane or chloranilic acid is 1 : 2. This proposed method has been applied to the determination of Azithromycin in tablets with satisfactory results. |
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| Keywords: | Charge-transfer reaction Spectrophotometry 7 7 8 8-tetracyanoquinodimethane(TCNQ) Azithromycin Chloranilic acid (CL) |
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