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傅里叶变换红外光谱应用于乳腺癌临床诊断的探索
引用本文:凌晓锋,徐智,徐怡庄,李庆波,周苏,张莉,赵红梅,侯纯升,王立新,侯宽永,周孝思,吴瑾光.傅里叶变换红外光谱应用于乳腺癌临床诊断的探索[J].光谱学与光谱分析,2005,25(2):198-200.
作者姓名:凌晓锋  徐智  徐怡庄  李庆波  周苏  张莉  赵红梅  侯纯升  王立新  侯宽永  周孝思  吴瑾光
作者单位:1. 北京大学第三医院普通外科,北京,100083
2. 北京大学化学学院,北京,100871
基金项目:国家自然科学基金重点项目(50203001,30371604),科技部“973”前期专项(2002CCA01900),教育部博士点基金资助
摘    要:应用了ATR探头测定了10例正常乳腺组织块和8例乳腺癌组织块的傅里叶变换红外(FTIR)光谱,用统计学的方法详细比较了乳腺癌组织与正常乳腺组织的13条谱带的19个红外光谱指标的差异。结果表明:乳腺癌组织的红外光谱中与蛋白质、脂类、碳水化合物和核酸相关的谱带同正常乳腺组织之间存在明显的差异:(1)N-H的相对强度明显增高,蛋白质酰胺Ⅰ带显著红移。(2)-CH2基团的对称伸缩振动和反对称伸缩振动以及C-O的伸缩振动明显减少;(-CH2)n变角振动的相对强度降低。(3)1160cm^-1谱带与1120cm^-1谱带的相对强度明显降低。(4)1080cm^-1谱带红移。这些差异是应用红外光谱诊断乳腺癌的基础。FTIR光谱在乳腺癌的临床诊断和治疗方面有着十分美好的前景。

关 键 词:乳腺癌组织  正常乳腺组织  临床诊断  CH  治疗方  增高  脂类  谱带  相对强度  红外光谱
文章编号:1000-0593(2005)02-0198-03
修稿时间:2004年11月6日

FTIR Spectroscopic Explorations of Clinical Practice of Breast Cancer
LING Xiao-feng,XU Zhi,XU Yi-zhuang,LI Qing-bo,ZHOU Su,ZHANG Li,ZHAO Hong-mei,HOU Chun-sheng,WANG Li-xin,HOU Kuan-yong,ZHOU Xiao-si,WU Jin-guang.FTIR Spectroscopic Explorations of Clinical Practice of Breast Cancer[J].Spectroscopy and Spectral Analysis,2005,25(2):198-200.
Authors:LING Xiao-feng  XU Zhi  XU Yi-zhuang  LI Qing-bo  ZHOU Su  ZHANG Li  ZHAO Hong-mei  HOU Chun-sheng  WANG Li-xin  HOU Kuan-yong  ZHOU Xiao-si  WU Jin-guang
Institution:Department of General Surgery, Third Hospital of Peking University, Beijing 100083, China.
Abstract:The authors detected ten normal breast tissue samples and eight breast cancer samples by FTIR spectroscopy with an ATR probe. Nineteen variables of thirteen bands in the spectra were compared using standard statistic methods. The results demonstrated that bands of protein, lipid, carbohydrate, and nucleic acid from cancerous samples were significantly different from those from normal ones: (1) The relative intensity of N-H band increased and amide I band shifted to lower wave number significantly; (2) Symmetric and antisymmetric vibrations of -CH2 group, C=O vibration, and relative intensity of (-CH2)n decreased; (3) The intensity of 1160 cm(-1) band was much weaker than that of 1120 cm(-1); (4) The band of P=O or P-O-C shifted toward lower wave number. The authors believe that FTIR spectroscopy has a promising future in breast cancer diagnosis.
Keywords:FTIR  Breast cancer  Clinical application exploration  
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