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Hg2+在大鼠组织器官中的分布及其存在形态研究
引用本文:沈金灿,黄志勇,庄峙厦,王小如,Lee Frank S C.Hg2+在大鼠组织器官中的分布及其存在形态研究[J].光谱学与光谱分析,2005,25(10):1688-1692.
作者姓名:沈金灿  黄志勇  庄峙厦  王小如  Lee Frank S C
作者单位:1. 厦门大学化学化工学院,现代分析科学教育部重点实验室,福建,厦门,361005
2. 集美大学生物工程学院,福建,厦门,361021
3. 厦门大学化学化工学院,现代分析科学教育部重点实验室,福建,厦门,361005;国家海洋局第一海洋研究所,山东,青岛,266061
4. 国家海洋局第一海洋研究所,山东,青岛,266061
基金项目:国家自然科学基金(20175022)资助项目
摘    要:汞是环境中重要的污染物之一,对人类的健康构成了巨大的威胁。文章通过建立电感耦合等离子体质谱及凝胶排阻色谱分离法与紫外和电感耦合等离子体质谱在线检测的联用技术,研究大鼠灌喂HgCl2后Hg在大鼠中的分布累积规律和及其与蛋白的结合,实验结果表明肝脏和肾脏中在Hg刺激下诱导产生大量硫蛋白,大量产生的金属硫蛋白可能因此而优先与通过胃肠吸收摄入的Hg结合,减少了Hg对其它蛋白的正常作用的干扰,从而大大降低了Hg^2+的毒性。

关 键 词:  SEC  UV  ICP-MS  金属硫蛋白
文章编号:1000-0593(2005)10-1688-05
收稿时间:2004-03-28
修稿时间:2004-06-16

Study on Hg2+ Distribution and Speciation in Different Tissues of Rats
SHEN Jin-can,HUANG Zhi-yong,ZHUANG Zhi-xia,WANG Xiao-ru,Lee Frank S C.Study on Hg2+ Distribution and Speciation in Different Tissues of Rats[J].Spectroscopy and Spectral Analysis,2005,25(10):1688-1692.
Authors:SHEN Jin-can  HUANG Zhi-yong  ZHUANG Zhi-xia  WANG Xiao-ru  Lee Frank S C
Institution:1. Department of Chemistry, The Key Laboratory of Analytical Sciences of the Ministry of Education, Xiamen University, Xiamen 361005, China;2. First institute Oceanography, S.O.A., Qindao 266061, China;3. College of Bioengineering, Jimei University, Xiamen 361021, China
Abstract:Mercury is one of the important pollutants that threaten people health greatly in environment. The purpose of this paper was to determine mercury distribution and mercury binding proteins in different tissues of rat fed orally with mercuric chloride by ICP-MS and SEC-UV-ICP-MS. The result showed that liver and kidney induced large amount of metallothioneins that was found to bind to mercury, copper and zinc after mercury intake in stomach and intestines. The metallothioneins induced may be prior to combine the mercury so that it would decrease mercury binding with the other proteins that would disable their normal function.
Keywords:Mercury  SEC  UV  ICP-MS  Metallothioneins
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