流动注射化学发光测定盐酸丙卡特罗

发现盐酸丙卡特罗(Procaterol hydrochloride)在硫酸介质 中能与铈(Ⅳ)和罗丹明B产生微弱的化学发光，而在该体系中加入盐酸和表面活性剂CTMAB，能显著增强化学发光的强度。探索了该化学发光体系最佳的反应条件，初步提出了该体系的反应机理，据此建立了流动注射化学发光测定盐酸丙卡特罗的新方法，线性响应范围为2×10-8g·mL-1～1×10-6g·mL-1,检出限为6×10-9g·mL-1； 对2.0×10-7g·mL-1盐酸丙卡特罗连续11次平行测定的相对标准偏差为1.6％，该方法用于测定盐酸丙卡特罗片剂并与标准方法(中国药典法)比较，结果令人满意。

Flow-Injection Chemiluminescence Determination of Procaterol Hydrochloride

A new flow injection chemiluminescences method for the determination of procaterol hydrochloride has been developed. It is based on the chemiluminescence reaction of procaterol hydrochloride with Ce (IV)-rhodamine B in sulphuric-chlorhydric acid medium and the experimental fact of the enhancement of chemiluminescence by surfactant CTMAB. The concentration of the analyte shows a good linear relationship with the produced luminescence intensity in the range of 2.0 x 10(-8) g x mL(-1) to 1.0 x 10(-6) g x mL(-1). The detection limit of the proposed method is 6 x 10(-9) g x mL(-1) and the RSD is 1.6% (n = 11) at 2 x 10(-7) g x mL(-1). This result is satisfactory compared with the method mentioned in the pharmacopoeia of People's Republic of China.