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| 直肠癌和直肠正常组织的傅里叶变换红外光谱研究 | |
| 引用本文： | 王凡,凌晓峰,杨展澜,徐智,任予,李维红,翁诗甫,吴瑾光.直肠癌和直肠正常组织的傅里叶变换红外光谱研究[J].光谱学与光谱分析,2003,23(3):498-501. |
| 作者姓名： | 王凡 凌晓峰 杨展澜 徐智 任予 李维红 翁诗甫 吴瑾光 |
| 作者单位： | 1. 北京大学化学与分子工程学院,化学生物学系,北京,100871 2. 北京大学第三医院,北京,100083 3. 西安交通大学第一医院,陕西,西安,710061 |
| 基金项目： | 国家自然科学基金 (2 9671 0 0 2 ,39730 1 60,2 0 0 2 30 0 5)，国家重点基础研究发展规划项目G1 9980 61 30 7，科技部前期研究专项 2 0 0 2CCA0 1 90 0资助 |
| 摘 要： | 利用傅里叶变换中红外 (FTIR)光纤和ATR技术研究了 2 1例直肠癌病人的正常和癌变组织。对319张光谱进行数据分析的结果表明 ,五个相对峰高 (I2 873 I2 854,I1 74 5 I1 6 43,I1 458 I1 40 0 ,I1 2 4 0 I1 31 5和I1 1 6 2 I1 0 82,单位为cm- 1 )的差别可用于区分直肠癌和直肠正常组织。用这一差别分析了距离直肠癌 1cm处组织的光谱 ,发现该组织处于正常和癌变的过渡状态。 |
| 关 键 词： | 傅里叶变换红外光谱(FTIR) 直肠癌 数据分析 |
| 文章编号： | 1000-0593(2003)03-0498-04 |
| 修稿时间： | 2002年11月10 |
FTIR Spectroscopic Study of Normal and Malignant Tissues of Rectum |
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| Fan Wang,Xiao-feng Ling,Zhan-lan Yang,Zhi Xu,Yu Ren,Wei-hong Li,Shi-fu Weng,Jin-guang Wu.FTIR Spectroscopic Study of Normal and Malignant Tissues of Rectum[J].Spectroscopy and Spectral Analysis,2003,23(3):498-501. | |
| Authors: | Fan Wang Xiao-feng Ling Zhan-lan Yang Zhi Xu Yu Ren Wei-hong Li Shi-fu Weng Jin-guang Wu |
| Institution: | College of Chemistry and Molecular Engineering, Department of Chemical Biology, Peking University, Beijing 100871, China. |
| Abstract: | Fourier transform infrared (FTIR) spectroscopy was used to study the normal and malignant tissues of rectum. The FTIR spectra of tissues were measured by Nicolet Magna IR-750 spectrometer equipped with mid-infrared fiber optics. The results show that the intensity ratios of five pairs of bands can be used to distinguish the normal and malignant tissues. In the spectra of malignant tissues the relative intensities ratios of I 2 873/I 2 852 and I 1 312/I 1 245 were higher than those of normal ones; however, the ratios of I 1 745/I 1 643,I 1 458/I 1 400 and I 1 162/I 1 082 were lower. These results, proved by data-analysis of spectra from 21 patients, were generally shown in the spectra of rectum tissues. The study of near-malignant tissues (one centimeter beside the malignant point) of rectum by FTIR shows that these ratios of bands were in a transient state between normal and malignant rectum tissues. |
| Keywords: | FTIR Malignant tissues of rectum Data-analysis |
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