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丹参配方颗粒红外无损快速分析研究
引用本文:吴婧,孙素琴,周群,郁露.丹参配方颗粒红外无损快速分析研究[J].光谱学与光谱分析,2007,27(8):1535-1538.
作者姓名:吴婧  孙素琴  周群  郁露
作者单位:清华大学化学系生命有机磷化学及化学生物学教育部重点实验室,北京,100084
摘    要:采用红外光谱法研究了丹参配方颗粒制备过程的质量控制,并对不同制药公司的丹参配方颗粒进行了分析.结果表明:1 160~1 000 cm-1糖类特征吸收峰波段,可用于判断所添加的辅料类型及含量,辅料相对含量越多,相应的辅料特征峰强度越大.1 608 cm-1附近的特征吸收峰,可用来评价丹参配方颗粒中有效成分的相对含量,该处相对峰强度越大,表明产品中丹参有效成分相对含量越高.因此红外光谱法可用于丹参配方颗粒的质量控制和制备工艺的判断.

关 键 词:傅里叶变换红外光谱法  丹参配方颗粒  质量控制
文章编号:1000-0593(2007)08-1535-04
修稿时间:2006-05-30

Study on Rapid and Nondestructive Analysis of Danshen Formula Particles by FTIR
WU Jing,SUN Su-qin,ZHOU Qun,YU Lu.Study on Rapid and Nondestructive Analysis of Danshen Formula Particles by FTIR[J].Spectroscopy and Spectral Analysis,2007,27(8):1535-1538.
Authors:WU Jing  SUN Su-qin  ZHOU Qun  YU Lu
Institution:Ministry of Education
Abstract:The authors applied Fourier transform infrared(FTIR) spectra to research the quality control of Danshen formula particles manufacturing process and to analyse formula particles from different pharmaceutical factories.The authors can confirm the sort and relative content of supplementary materials by the characteristic absorption peaks of sugar in the range from 1 160 to 1 000 cm-1.The intensity of absorption peaks becomes stronger when the relative content of supplementary materials is higher.The authors can evaluate the relative content of effective component in danshen formula particles by the characteristic absorption peaks at 1 608 cm-1.The intensity of absorption peaks becomes stronger when the relative content of the effective component is higher.FTIR spectrometry is an effective and fast method not only for the quality control of Danshen formula particles,but also for identifying the manufacturing technics.
Keywords:FTIR  Danshen formula particles  Quality control
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