σ-电子受体试剂与硫酸阿托品的电荷转移反应及应用研究

本文研究了硫酸阿托品与I2 在氯仿溶液中的荷移反应并探讨其反应机理 ,指出I2 为电子受体 ,硫酸阿托品为电子给体 ,经试验知形成 1∶1的复合物。其λmax=2 80nm ,表观摩尔系数为 2 6 6× 10 4L·mol- 1 ·cm- 1 ,确定了用此原理测定硫酸阿托品的方法及最佳条件 ,比尔定律线性范围 0～ 35 μg·mL- 1 ,本法测定简便、快捷、选择性强

Charge Transfer Interaction of Atropinum with σ-Electron Acceptor and Application Research

The charge transfer interaction of vitriol atropinum with iodine in the chloroform was studied. Iodine interacts with atropinum in the chloroform and forms the purple and brown charge transfer complexation. From the ultraviolet spectrum, it is confirmed that the maximum wavelength of the complexation is 280 nm and the apparent molar absorptivities of the complexation is 2.66 x 10(4) L.mol-1.cm-1. Using the equal mole consecutive change method, it is confirmed that the molar combining ratio is 1:1. The reaction mechanism is studied and it is confirmed that the complexation is a kind of supramolecule compound, which is in the syntonic mixed state of non-bonding structure and charge transfer. On the base of the complexation, the method that is used to determine vitriol atropinum injection by the charge transfer spectrophotometry is founded. And the optimal condition of the method was studied. The experiment showed that when the volume ratio of iodine and vitriol atropinum was 2:1, the value of the absorbency of the reaction system was almost stable and the reaction should last out for 20 minutes at room temperature. The method is simple and convenient, short-cut, exclusive. The linear range is 0-35 micrograms.mL-1, the reclaim rate is 99.6%, RSD is 0.83%.