| 导数光谱法同时测定甲硝唑和维生素B6的研究 |
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| 引用本文： | 张淑芳,张冬梅.导数光谱法同时测定甲硝唑和维生素B6的研究[J].光谱学与光谱分析,1998,18(4):488-491. |
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| 作者姓名： | 张淑芳 张冬梅 |
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| 作者单位： | 曲阜师范大学化学系 |
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| 摘 要： | 本建立了以０．１ｍｏｌ／ＬＨＣｌ为介质，采用三阶导数光谱法，同时测定甲硝唑和维生素Ｂ６的新方法，方法检测限为０．８１μｇ／ｍＬ甲硝唑和０．１６μｇ／ｍＬ维生素Ｂ６，二测定的线性范围均为１．６－２２．４μｇ／ｍＬ，直接用于复方甲硝唑片剂中甲硝唑和维生素Ｂ６的测定，两种生物的测定变异系数分别小于２．２６和２．６０％，回收率分别为９３－１０２％和９９－１０１％．
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| 关 键 词： | 导数光谱法 甲硝唑 维生素B6 复方甲硝唑 测定 |
Simultaneous determination of metronidazolum and vitamin B6 by the derivative spectrophotometry] |
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| S Zhang,H Li,D Zhang,Q Zhou.Simultaneous determination of metronidazolum and vitamin B6 by the derivative spectrophotometry][J].Spectroscopy and Spectral Analysis,1998,18(4):488-491. |
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| Authors: | S Zhang H Li D Zhang Q Zhou |
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| Institution: | Department of Chemistry, Qufu Normal University, 273165 Qufu. |
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| Abstract: | A new method for simultaneous determination of metronidazolum and vitamin B6 was established by the third derivative spectrophotometry in 0.1 mol/L HCl solution. The detection limits were 0.81 microg/mL for metronidazolum and 0.16 microg/mL for vitamin B6. The linear range of determination was 1.6-22.4 microg/mL for both metronidazolum and vitamin B6. This method has been applied to the determination of metronidazolum and vitamin B6 in tabellae metronidazoli compositae with satisfactory results. The coefficients of variation are below 2.26 and 2.65% and the recoveries are 93-102% and 99-101% for metronidazolum and vitamin 6, respectively. |
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