| 桂利嗪的荷移分光光度法测定 |
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| 引用本文： | 徐变珍,赵凤林.桂利嗪的荷移分光光度法测定[J].光谱学与光谱分析,1999,19(6):886-888. |
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| 作者姓名： | 徐变珍 赵凤林 |
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| 作者单位： | 北京大学化学与分子工程学院 |
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| 摘 要： | 本研究了桂利嗪与７．７，８，８－四氰基对二次甲苯醌（ＴＣＮＱ）的荷移（ＣＴ）反应，确定了荷移反应的最佳条件。结果表明：在丙酮－甲醇介质中，二于室温条件下１０ｍｉｎ即可形成１：１的络合物，在其最大吸收波长７４３ｎｍ处表观摩尔吸光系数ε＝１．５８×１０＾４Ｌ·ｍｏｌ＾－１·ｃｍ＾－１，在０～１８μｇ·ｍＬ＾－１范围内符合比尔定律。方法的相对标准偏差小于３％（ｎ＝１０）。对形成ＣＴ络合物的机理进行了
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| 关 键 词： | 荷移反应 TCNQ 分光光度法 桂利嗪 测定 |
Spectrophotometric Determination of Cinnarizine Based on Charge-transfer Reaction |
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| B Xu,F Zhao,S Tong.Spectrophotometric Determination of Cinnarizine Based on Charge-transfer Reaction[J].Spectroscopy and Spectral Analysis,1999,19(6):886-888. |
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| Authors: | B Xu F Zhao S Tong |
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| Institution: | Department of Chemistry, Peking Universtiy, 100871 Beijing. |
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| Abstract: | The charge-transfer (CT) complex formed between cinnarizine as the donor and 7, 7, 8, 8-Tetracyanoquinodimethane (TCNQ) as the acceptor in acetone-methanol has been studied by spectrophotometric method. Beer's law is obeyed in the range of 0-18 microg x mL(-1) of cinnarizine. The apparent molar absorptivity of CT complex at 743 nm is 1.58 x 10(4) L x mol(-1) x cm(-1). The composition of CT complex is found to be 1 : 1 by Bent-French and Job's methods. The relative standard deviation is less than 3% (n = 10). The method has been applied to the determination of cinnarizine in tablets with satisfactory results. |
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| Keywords: | Charge transfer reaction TCNQ Spectrophotometry Cinnarizine |
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