多种糖混合物的太赫兹时域光谱定性及定量分析研究

利用太赫兹时域光谱(terahertz time-domain spectroscopy,THz-TDS)技术研究了D-(-)-核糖、D-葡萄糖、α-乳糖一水合物及β-乳糖在0.3～1.6 THz波段的光谱特性.结果显示THz波对几种糖结构的变化有灵敏响应,在测量波段内有各自特征的THz指纹吸收光谱.利用线性回归技术对含两至四组分混合体系的THz光谱进行定性及定量解析,获得了混合物中各组分含量,相对误差小于7.2%,并就误差产生的原因做了简要分析.实验结果表明THz-TDS技术能够用于材料的定性及定量分析研究,在生物医药的无损检测和质量控制等方面有重要的应用前景.

Qualitative and Quantitative Analyses of Some Saccharides by THz-TDS

Terahertz (THz) radiation lies between the infrared and microwave range of the electromagnetic spectrum. Absorption spectrum in the THz range provides rich information about structure and weak interactions of biomolecules. THz absorption spectra of D-(-)-ribose, D-glucose, α-lactose monohydrate and β-lactose were measured by terahertz time-domain spectroscopy (THz-TDS) in the frequency range of 03-16 THz at room temperature. The experimental results show that different saccharides have distinct THz absorption features, which suggests that THz-TDS is highly sensitive to molecular structures and components. Quantitative analysis of the mixtures of two to four saccharides was studied by linear regression with relative error less than 72%. The reasons for the relative error were discussed. The results demonstrate that THz-TDS is a promising and efficient method for both qualitative and quantitative analyses for pharmaceutical identification and biomolecular detection.