阿莫西林的太赫兹光谱研究

阿莫西林是一种青霉素类抗生素,由于其独特的药效,在临床和人们的日常生活中应用比较广泛.对于这类药物的真伪检测不仅关系到患者的身心健康,而且对于保护合法生产厂商利益打击假冒伪劣药品都极为重要.太赫兹(THz)波是一种新开发的电磁辐射,具有许多独特性质.利用基于太赫兹波的太赫兹时域光谱技术对3个不同厂家生产的阿莫西林胶囊进行了测试分析,得到了三种样品的太赫兹时域光谱,通过傅里叶变换,得到了它们的频域光谱,同时获得了它们的太赫兹吸收系数曲线和折射率曲线.测试结果表明三种样品在太赫兹波段存在明显的吸收峰,在0.20～1.60 THz之间,吸收峰的位置基本上是重合的,三种样品的折射率存在一定的差别.对阿莫西林太赫兹时域光谱的研究表明:太赫兹波在青霉素类药品的质量检查、药品生产过程中的质量控制以及假冒伪劣药品的打击方面有广阔的应用前景.

The Inspection of Amoxicillin Medicines Studied by the Terahertz Time-Domain Spectroscopy Technique

The amoxicillin medicines are widely used in the clinical medicine and ordinary life.The inspection of them is vitally important to the health of the patients and the protection of the legal manufactures.Terahertz is a newly developed electromagnetic radiation with many characteristic properties.In the present paper,three amoxicillin capsules produced by three different companies were studied by the terahertz time-domain spectroscopy technique.The time-domain spectra and the frequency-domain spectra were obtained,and consequently both the absorption coefficient and the refraction index were calculated.The results indicated that the absorption coefficient of the three samples were almost the same,while the refractive indexes of them were different to some extent.It is suggested that the terahertz time-domain spectroscopy is a powerful candidate technique in the quality inspection of penicillin medicines and the crackdowr on the fake drugs.