水杨醛氨基酸席夫碱水溶液的电子光谱研究

通过电子光谱研究了7种水杨醛氨基酸席夫碱配体Salaa在水溶液中的生成情况。Saltyr的生成浓度下限为10-5mol·L-1,其余6种Salaa的生成浓度下限均为10-4mol·L-1。除Salhis的生成pH为9～10外,其余6种Salaa都是pH值增大有利于席夫碱生成。Salgly和Saltyr的生成pH下限为8,其余4种Salaa的pH下限为9。Salcys水溶液放置36h后席夫碱浓度比新生成溶液的大,其余6种Salaa都是自生成后就开始缓慢分解。Salgly和Salglu水溶液的相对稳定存在时间为24h,其余4种Salaa的相对稳定存在时间为48h。本工作为探索用于放射性药物研究的水杨醛氨基酸席夫碱水溶液标记放射性核素提供了实验基础。

Electronic Spectral Study on Salicylaldehyde-Amino Acid Schiff Bases in Water

Seven salicylaldehyde-amino acid Schiff bases in water were investigated by means of electronic spectra, which is helpful to investigate the label of radionuclides with the seven ligands in water for radiopharmaceutical study. Except 10(-5) mol x L(-1) for Sal-tyr, the minimum concentration of formation is 10(-4) mol x L(-1) for all other Sal-aas. Only Sal-his is generated at pH 9-10, while the minimum pH conditions for formation are 8 for Sal-gly and Sal-tyr, and 9 for other four. All Sal-aa but Sal-cys, whose concentration at 36 h is higher than that of newly produced one, decompose gradually since generation, with existing time of 24 h for Sal-gly and Sal-glu, and 48 h for other four.