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甲氧氯普胺和盐酸普鲁卡因顺序注射光谱研究和测定
引用本文:王爱军,樊静,冯素玲,崔凤灵.甲氧氯普胺和盐酸普鲁卡因顺序注射光谱研究和测定[J].光谱学与光谱分析,2005,25(3):432-435.
作者姓名:王爱军  樊静  冯素玲  崔凤灵
作者单位:河南师范大学化学与环境科学学院,河南省高等学校环境科学与工程重点学科开放实验室,河南,新乡,453002
基金项目:河南省自然科学基金 (0 2 1 1 0 2 0 2 0 0 ),河南省教育厅自然科学基金 (2 0 0 1 61 0 0 0 0 5)资助项目
摘    要:在酸性介质中 ,铈 (Ⅳ )与甲氧氯普胺和盐酸普鲁卡因反应生成不稳定的红色产物 ,研究了不同条件下的光谱吸收曲线 ,初步探讨了反应机理 ,并据此建立了顺序注射光度法测定甲氧氯普胺和盐酸普鲁卡因的新方法。测定甲氧氯普胺方法的线性范围 9 71~ 116 . 6 μg·mL-1,检出限 6 . 5 μg·mL-1,进样频率 4 5h-1。测定盐酸普鲁卡因的方法的线性范围 10. 0~ 130 . 0 μg·mL-1,检出限 7 4 μg·mL-1,进样频率 4 5h-1。用于针剂和胃复安药片中甲氧氯普胺的含量以及针剂中盐酸普鲁卡因含量的测定 ,并与标准测定方法对照 ,经统计学处理无显著性差异 ,结果满意。

关 键 词:甲氧氯普胺  盐酸普鲁卡因  经统计学处理  胃复安  针剂  对照  药片  进样  光谱研究  顺序注射
文章编号:1000-0593(2005)03-0432-04
修稿时间:2003年9月26日

Spectral Study and Determination of Metoclopramide and Procaine Hydrochloride by Sequential Injection Analysis
WANG Ai-jun,FAN Jing,FENG Su-ling,CUI Feng-ling.Spectral Study and Determination of Metoclopramide and Procaine Hydrochloride by Sequential Injection Analysis[J].Spectroscopy and Spectral Analysis,2005,25(3):432-435.
Authors:WANG Ai-jun  FAN Jing  FENG Su-ling  CUI Feng-ling
Institution:School of Chemical and Environmental Sciences, Key Laboratory of Environmental Science and Engineering of Henan Education Departmnent, Henan Normal University, Xinxiang 453002, China.
Abstract:A sequential injection spectrophotometric method is proposed for the determination of metoclopramide or procaine hydrochloride, based on the reactions of metoclopramide and procaine hydrochloride with cerium(IV) in sulfuric acid medium. Red intermediate products were observed and were found unstable so that their analytical use is only possible by sequential injection technology. For metoclopramide, the detection limit is 6.5 microg x mL(-1), and the linear range of determination is 9.7-116.6 microg x mL(-1) with a sampling frequency of 45 h(-1). For procaine hydrochloride, the detection limit is 7.4 microg x mL(-1), and the linear range of the determination is 10.0-130.0 microg x mL(-1) with a sampling frequency of 45 h(-1). The method has been applied to the determination of metoclopramide and procaine hydrochloride in tablets and injections with satisfactory results as compared with standard method.
Keywords:Sequential injection analysis  Metoclopramide  Procaine hydrochloride
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