| 流动注射抑制化学发光法测定痕量强力霉素 |
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| 引用本文： | 李念兵,段建平,陈红青,陈国南.流动注射抑制化学发光法测定痕量强力霉素[J].光谱学与光谱分析,2004,24(1):15-17. |
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| 作者姓名： | 李念兵 段建平 陈红青 陈国南 |
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| 作者单位： | 1. 福州大学化学化工学院,福建,福州,350002
2. 福州大学分析测试中心,福建,福州,350002 |
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| 基金项目： | 国家自然科学基金 (2 0 1 750 0 5)，福州大学博士后基金，福州大学科学发展基金资助项目 |
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| 摘 要： | 基于在NaOH介质中 ,强力霉素对Luminol KMnO4 体系发光反应具有强烈的抑制作用 ,建立起流动注射抑制化学发光测定痕量强力霉素的新方法。强力霉素在 0 0 0 5～ 5 0 μg·mL- 1 浓度范围内 ,采用不同的KMnO4 溶液浓度 ,分段建立起抑制化学发光强度与其浓度间良好的线性关系 ,方法的检出限为 2 0×10 - 3μg·mL- 1 。该方法可用于药片中强力霉素含量的测定
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| 关 键 词： | 强力霉素 流动注射 抑制化学发光 |
| 文章编号： | 1000-0593(2004)01-0015-03 |
| 修稿时间： | 2002年11月16 |
Flow Injection Analysis of Trace Amounts of Doxycycline with Inhibited Chemiluminescence Detection |
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| LI Nian-bing ,DUAN Jian-ping ,CHEN Hong-qing ,CHEN Guo-nan . College of Chemistry and Chemical Engineering,Fuzhou University,Fuzhou ,China . Analytical and Testing Center,Fuzhou University,Fuzhou ,China.Flow Injection Analysis of Trace Amounts of Doxycycline with Inhibited Chemiluminescence Detection[J].Spectroscopy and Spectral Analysis,2004,24(1):15-17. |
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| Authors: | LI Nian-bing DUAN Jian-ping CHEN Hong-qing CHEN Guo-nan College of Chemistry and Chemical Engineering Fuzhou University Fuzhou China Analytical and Testing Center Fuzhou University Fuzhou China |
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| Institution: | College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China. |
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| Abstract: | A novel flow injection chemiluminescence method has been developed for the determination of doxycycline (DC) based on the inhibition of chemiluminescence reaction of Luminol-KMnO4 by using DC in sodium hydroxide medium. Using different concentrations of KMnO4, a series of good linear regression equations of decreased chemiluminescence intensity and the concentration of DC were obtained with different subsections in the concentration range of 0.005-5.0 microg x mL(-1). The detection limit (3sigma) is 2.0 x 10(-3) microg x mL(-1). The method has been successfully applied to the determination of DC in a pharmaceutical preparation. |
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| Keywords: | Doxycycline Flow injection Inhibitory chemiluminescence |
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