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| 荧光光谱法研究共存碳纳米管对牛血清白蛋白与加替沙星相互作用的影响 | |
| 作者姓名： | Zha J He H Liu TB Li SS Jiao QC |
| 作者单位： | 1. 中国药科大学分析化学教研室,江苏南京,210009 2. 中国药科大学分析化学教研室,江苏南京,210009;药物质量与安全预警教育部重点实验室,江苏南京,210009 3. 浙江科技学院中德农产品加工业研究院,浙江杭州,310023 4. 南京大学生命科学学院医药生物技术国家重点实验室,江苏南京,210093 |
| 基金项目： | 中国药科大学科学研究经费资助 |
| 摘 要： | 在模拟生理条件下,用荧光光谱法研究了碳纳米管对牛血清白蛋白和加替沙星荧光光谱特性的影响以及有无碳纳米管共存时加替沙星对牛血清白蛋白荧光光谱特性的影响.实验结果表明,加替沙星和碳纳米管都可以使牛血清白蛋白的荧光强度发生静态猝灭.在碳纳米管的存在下,加替沙星与牛血清白蛋白的结合作用有所减弱.Stern-Volmer荧光猝灭... |
| 关 键 词： | 碳纳米管 牛血清白蛋白 加替沙星 荧光猝灭 同步荧光 |
Studies on the interaction of gatifloxacin with bovine serum albumin in the presence of carbon nanotubes by fluorescence spectroscopy |
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| Zha J,He H,Liu TB,Li SS,Jiao QC.Studies on the interaction of gatifloxacin with bovine serum albumin in the presence of carbon nanotubes by fluorescence spectroscopy[J].Spectroscopy and Spectral Analysis,2011,31(1):149-153. | |
| Authors: | Zha Jun He Hua Liu Tie-Bing Li Shan-Shan Jiao Qing-Cai |
| Institution: | ZHA Jun1,HE Hua1,4*,LIU Tie-bing2,LI Shan-shan1,JIAO Qing-cai3 1.Division of Analytical Chemistry,China Pharmaceutical University,Nanjing 210009,China 2.The Sino-Germany Institute of Agriculture Products Processing Industry,Zhejiang University of Science and Technology,Hangzhou 310023,China 3.State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,China 4.Key Laboratory of Drug Quality Control and Pharmacovigilance of Ministry of Education(China Pharmaceutical University),Nanj... |
| Abstract: | Fluorescence spectroscopy was used to investigate the influences of carbon nanotubes(CNTs) on the fluorescence of bovine serum albumin(BSA),the influences of CNTs on that of gatifloxacin(GFLX),and the influences of GFLX on that of BSA with or without coexisting CNTs under imitated physiological condition.The experimental results demonstrate that both gatifloxacin and carbon nanotubes could quench the intrinsic fluorescence of BSA,and the quenching mechanism is mainly static quenching.The fluorescence quench... |
| Keywords: | Carbon nanotubes Gatifloxacin Bovine serum albumin Fluorescence quenching Synchronous fluorescence |
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