热凝固致人肝组织光衰减和光穿透深度的变化

采用双积分球和反向倍增法(IAD)，研究了热凝固致人肝肿瘤及正常人肝组织对680, 720,780,810, 850, 890 nm波长的钛宝石激光的光穿透深度和光衰减特性的变化。结果表明：6个波长的激光的热凝固前后的肝肿瘤和正常肝对光穿透深度都随着激光波长的增大而明显增大，热凝固后的激光穿透深度都分别显著地较热凝固前的穿透深度小(P＜0.05)，6个波长的激光对热凝固前后的肝肿瘤的光穿透深度都分别显著地较热凝固前后的正常肝穿透深度大(P＜0.05)。热凝固前后的人肝肿瘤和正常肝对6个波长的激光的衰减都是随着激光波长的增大而明显减小，热凝固后的人肝肿瘤和正常肝的光衰减都分别显著地较热凝固前的衰减大(P＜0.05)，热凝固前后的肝肿瘤对光的衰减也都分别显著地较热凝固前后的正常肝衰减大(P＜0.05)。

Comparison of Light Attenuation Characteristics and Optical Penetration Depths between Native and Coagulated Human Liver Tissues

A double-integrating-spheres and IAD method were used to study the differences in the optical penetration depths (OPDs) and light attenuation (LA) native and coagulated human liver tumors and liver tissues at the wavelengths of 680, 720, 780, 810, 850 and 890 nm of Ti:Sapphire laser. The results of measurement showed that the OPDs for native and coagulated human liver tumors and liver tissues at six different wavelengths obviously increase with increasing laser wavelength, the OPDs of coagulated human liver tumors and liver tissues at six different wavelengths were significantly smaller than that of native human liver tumors and liver tissues at the same wavelength respectively (P<0.05), and the OPDs of native and coagulated human liver tumors at six different wavelengths were significantly bigger than that of native and coagulated human liver tissues at the same wavelength respectively (P<0.05). The LA for native and coagulated human liver tumors and liver tissues at six different wavelengths obviously decreases with increasing laser wavelength, and the LA for coagulated human liver tumors and liver tissues at six different wavelengths is significantly bigger than that for native human liver tumors and liver tissues at the same wavelength respectively (P<0.05). The LA for native and coagulated human liver tumors at six different wavelengths is significantly bigger than that for native and coagulated human liver tissue at the same wavelength respectively (P<0.05).