微波消解/ICP-MS法测定川黄柏中微量重金属元素

采用微波消解技术，建立了一种测定道地药材川黄柏中Co，Ni，Cu，Zn，As，Cd，Hg和Pb等八种微量重金属元素的ICP-MS法。用国家一级标准物质杨树叶(GBW—07604)和茶叶(GBW—07605)标准物质评价了方法的准确性。应用拟定的分析方法测定了不同地区(巴中、宜宾与荥经)、不同生长期(荥经：6年、8年10年)的川黄柏中微量重金属元素的含量。方法对试样中各元素测定的相对标准偏差范围为3.2％～17.8％，回收率在70％～120％之间。研究表明，方法简便、快速、灵敏，适合于川黄柏中八种微量重金属元素的测定。同时，试样分析结果显示，川黄柏中有害重金属元素As，Cd，Hg和Pb的含量均低于《中国药典》及《药用植物及制剂进出口绿色行业标准》的限量标准，宜于药用和出口。

Determination of Trace Heavy Metal Elements in Cortex Phellodendri Chinensis by ICP-MS after Microwave-Assisted Digestion

An inductively coupled plasma mass spectrometry(ICP-MS) for determination of the contents of 8 trace heavy metal elements in cortex phellodendri chinensis after microwave-assisted digestion of the sample has been developed.The accuracy of the method was evaluated by the analysis of corresponding trace heavy metal elements in standard reference materials(GBW 07604 and GBW 07605).By applying the proposed method,the contents of 8 trace heavy metal elements in cortex phellodendri chinensis cultivated in different areas(in Bazhong,Yibin and Yingjing,respectively) of Sichuan and different growth period(6,8 and 10 years of samples from Yingjing) were determined.The relative standard deviation(RSD) is in the range of 3.2%-17.8% and the recoveries of standard addition are in the range of 70%-120%.The results of the study indicate that the proposed method has the advantages of simplicity,speediness and sensitivity.It is suitable for the determination of the contents of 8 trace heavy metal elements in cortex phellodendri chinensis.The results also show that the concentrations of 4 harmful trace heavy metal elements As,Cd,Hg and Pb in cortex phellodendri chinensis are all lower than the limits of Chinese Pharmacopoeia and Green Trade Standard for Importing and Exporting Medicinal Plant and Preparation.Therefore,the cortex phellodendri chinensis is fit for use as medicine and export.