| 微过氧化物酶-8的聚集程度对其与La3+相互作用的影响 |
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| 引用本文： | 陈婷婷,黄晓华,杜江燕,冯玉英,刘长鹏,邢巍,陆天虹.微过氧化物酶-8的聚集程度对其与La3+相互作用的影响[J].光谱学与光谱分析,2005,25(8):1270-1273. |
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| 作者姓名： | 陈婷婷 黄晓华 杜江燕 冯玉英 刘长鹏 邢巍 陆天虹 |
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| 作者单位： | 南京师范大学化学与环境科学学院,江苏,南京,210097;中国科学院长春应用化学研究所,吉林,长春,130022;南京师范大学化学与环境科学学院,江苏,南京,210097;中国科学院长春应用化学研究所,吉林,长春,130022 |
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| 基金项目： | 国家自然科学基金（20243002）、国家计委稀土专项基金（GJx01100626）、江苏省科技厅高新技术基金（BG2001045）、江苏省教育厅高校自然科学基金（01KJB150006,2000LHZ0000SJ1,02KJB150006）和国家“211”工程重点学科建设资助项目 |
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| 摘 要： | UV-Vis吸收光谱的结果表明,由于La3 与微过氧化物酶-8(MP-8)分子血红素上的两个丙酸基的羧基氧发生强的键合作用,使血红素卟啉环的非平面性增加。NaCl能增加MP-8分子的聚集程度,导致La3 与MP-8相互作用引起的血红素卟啉环的非平面性增加的程度大大降低。甲醇虽然能降低MP-8的聚集程度,但对La3 与MP-8分子相互作用引起血红素卟啉环的非平面性增加程度的影响较小。
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| 关 键 词： | 微过氧化物酶-8 La3+ 紫外-可见吸收光谱 |
| 文章编号： | 1000-0593(2005)08-1270-04 |
| 收稿时间： | 03 5 2004 12:00AM |
| 修稿时间： | 06 26 2004 12:00AM |
Effect of Aggregation Extent of Microperoxidase-8 on Its Interaction with La3+ |
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| CHEN Ting-ting,HUANG Xiao-hua,DU Jiang-yan,FENG Yu-ying,LIU Chang-peng,XING Wei,LU Tian-hong.Effect of Aggregation Extent of Microperoxidase-8 on Its Interaction with La3+[J].Spectroscopy and Spectral Analysis,2005,25(8):1270-1273. |
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| Authors: | CHEN Ting-ting HUANG Xiao-hua DU Jiang-yan FENG Yu-ying LIU Chang-peng XING Wei LU Tian-hong |
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| Institution: | College of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, China. |
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| Abstract: | The results of UV-Vis Absorption spectroscopic investigation indicated that La~(3 ) coordinates strongly with carboxylate (oxygen) of two propionic acid groups of the (heme) group in an MP-8 molecule, leading to an increase in the non-planarity of the (porphyrin) ring of the heme group. The increasing extent in the non-planarity of the porphyrin ring of the heme group due to the (interaction) of La~(3 ) and MP-8 molecule would be significantly decreased because NaCl could increase the aggregation extent of MP-8 molecules. Although methanol can reduce the aggregation extent of MP-8 molecules, it has little influence on the increasing extent in the non-planarity of the porphyrin ring of the heme group due to the interaction of La~(3 ) and MP-8 molecule. |
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| Keywords: | Microperoxidase-8 La~(3 ) UV-Vis Absorption spectroscopy |
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