| 流动注射化学发光法测定诺氟沙星 |
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| 引用本文： | 廖素兰,谢增鸿.流动注射化学发光法测定诺氟沙星[J].光谱学与光谱分析,2005,25(12):1938-1942. |
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| 作者姓名： | 廖素兰 谢增鸿 |
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| 作者单位： | 1. 福州大学化学系，福建 福州 350002
2. 南平师范高等专科学校，福建 南平 353000 |
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| 基金项目： | 福建省自然科学基金（D0310010）和福建省科技攻关资助项目（2003Y005,2002Y051） |
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| 摘 要： | 在酸性条件下，Ce(Ⅳ)与诺氟沙星(NFLX)能产生弱的化学发光反应，十二烷基硫酸钠(SDS)对其有较强的增敏作用。据此建立了一种简单、快速、可连续测定诺氟沙星的流动注射化学发光新方法。该法线性范围7.78×10-8～5.82×10-6 g·mL-1 ，检测限(3σ)为1.57×10-8 g·mL-1，对1.94×10-6 g·mL-1 的NFLX标准溶液平行测定10次，相对标准偏差为1.7%。该法成功应用于诺氟沙星胶囊的测定, 还对其机理进行了初步探讨。
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| 关 键 词： | 化学发光 诺氟沙星 流动注射 |
| 文章编号： | 1000-0593(2005)12-1938-05 |
| 收稿时间： | 2004-09-02 |
| 修稿时间： | 2004-12-16 |
Determination of Norfloxacin by Flow-Injection Chemiluminescence |
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| LIAO Su-lan,XIE Zeng-hong.Determination of Norfloxacin by Flow-Injection Chemiluminescence[J].Spectroscopy and Spectral Analysis,2005,25(12):1938-1942. |
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| Authors: | LIAO Su-lan XIE Zeng-hong |
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| Institution: | 1. Department of Chemistry, Fuzhou University, Fuzhou 350002，China2. Nanping Teachers College, Nanping 353000，China |
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| Abstract: | Sodium dodecylsulfate (SDS) can greatly enhance the emission intensity of the weak chemiluminescence reaction of Ce (IV) with norfloxacin (NFLX) in acid medium. Based on this phenomenon, a simple and rapid new method for the continuous determination of norfloxacin was developed. The calibration graph is linear for 7.78 x 10(-8) -5.82 x 10(-6) g x mL(-1), the detection limit (3sigma) is 1.57 x 10(-8) g x mL(-1), and the relative standard deviation (n = 10, c = 1.94 x 10(-6) g x mL(-1)) is 1.7%. The method was successfully applied to the determination of norfloxacin in capsules. Additionally, the system's mechanism was discussed. |
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| Keywords: | Chemiluminescence Norfloxacin Flow-injection |
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