| Institution: | (1) Department of Biology, University of Colorado at Colorado Springs, Colorado Springs, CO 80933-7150, USA;(2) Natural Sciences Division, Seaver College, Pepperdine University, Malibu, CA 90263, USA;(3) Hollis Eden Pharmaceuticals, San Diego, CA 92121, USA;(4) Department of Physics, University of Colorado at Colorado Springs, Colorado Ssprings, CO 80933-7150, USA;(5) Cancer Research Institute, Arizona State University, Tempe, AZ 85287, USA |
| Abstract: | A widely held view is that oncolytic agents induce death of tumor cells directly. In this report we review and discuss the
apoptosis-inducing effects of chemotherapeutics, the effects of chemotherapeutics on metabolic function, and the consequent
effects of metabolic function on immune recognition. Finally, we propose that effective chemotherapeutic and/or apoptosis-inducing
agents, at concentrations that can be achieved physiologically, do not kill tumor cells directly. Rather, we suggest that effective oncolytic agents sensitize immunologically altered tumor cells
to immune recognition and immune-directed cell death. |
