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Fluctuation theorem for the mutation process in in vitro evolution |
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| Authors: | Liu Qi Tang Chao and Ouyang Qi |
| Institution: | Center for Theoretical Biology, Peking University, Beijing {\rm 100871, China;California Institute for Quantitative Biomedical Research, Departments of Biopharmaceutical Sciences and Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA; Department of Physics, Peking University, Beijing 100871, China;Center for Theoretical Biology, Peking University, Beijing {\rm 100871, China |
| Abstract: | A proposition based on the fluctuation theorem in thermodynamics is formulated to quantitatively describe molecular evolution processes in biology. Although we cannot give full proof of its generality, we demonstrate via computer simulation its applicability in an example of DNA in vitro evolution. According to this theorem, the evolution process is a series of exponentially rare fluctuations fixed by the force of natural selection. |
| Keywords: | fluctuation theorem molecular evolution natural selection |
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