| Controlling intracellular Ca2+ spiral waves by the local agonist in the cell membrane |
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| 作者姓名： | 仇康 唐军 马军 罗继明 |
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| 作者单位： | Department of Mathematics and Physics, Xuzhou Medical College,
Xuzhou 221004, China;College of Science, China University of Mining and Technology,
Xuzhou 221008, China;Department of Physics, Lanzhou University of Technology, Lanzhou
730050, China;College of Science, China University of Mining and Technology,
Xuzhou 221008, China |
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| 基金项目： | Project supported by the Xuzhou
Medical College Foundation, China (Grant No.~08kj08). |
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| 摘 要： | A modified spatially extended Tang-Othmer Ca2+ model is used to study intracellular Ca2+ spiral waves numerically.It is found that,as a local stimulation,the local agonist-binding on the cell membrane,which enhances the local concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP 3),can influence the dynamics of the spiral waves.1) Strong enough stimuli can change the spiral wave from a meandering to a rigidly rotating one.2) On the other hand,strong enough stimuli can suppress the spiral wave from the system.It provides the theoretical clue for controlling the spiral waves by stimulating the cell membrane.
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| 关 键 词： | spiral wave local stimuli calcium signaling IP 3 |
| 收稿时间： | 2009-07-30 |
| 修稿时间： | 9/6/2009 12:00:00 AM |
Controlling intracellular Ca2+ spiral waves by the local agonist in the cell membrane |
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| Qiu Kang,Tang Jun,Ma Jun and Luo Ji-Ming.Controlling intracellular Ca2+ spiral waves by the local agonist in the cell membrane[J].Chinese Physics B,2010,19(3):30508-030508. |
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| Authors: | Qiu Kang Tang Jun Ma Jun and Luo Ji-Ming |
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| Institution: | College of Science, China University of Mining and Technology,
Xuzhou 221008, China; Department of Mathematics and Physics, Xuzhou Medical College,
Xuzhou 221004, China; Department of Physics, Lanzhou University of Technology, Lanzhou
730050, China |
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| Abstract: | A modified spatially extended Tang--Othmer Ca2+
model is used to study intracellular Ca2+ spiral waves
numerically. It is found that, as a local stimulation, the local
agonist-binding on the cell membrane，which enhances the local
concentration of the messenger molecule inositol
1,4,5-trisphosphate(IP3), can influence the dynamics of the
spiral waves. {1}) Strong enough stimuli can change the spiral wave
from a meandering to a rigidly rotating one. {2}) On the other hand,
strong enough stimuli can suppress the spiral wave from the system.
It provides the theoretical clue for controlling the spiral waves by
stimulating the cell membrane. |
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| Keywords: | spiral wave local stimuli calcium signaling IP3 |
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