Abstract: | We directly introduce a Bell-type inequality for four-qubit systems. Using the inequality we investigate quantum nonlocality of a generic family of states |GabcdPhys. Rev. A 65 052112(2002)] and several canonical four-qubit entangled states. It has been demonstrated that the inequality is maximally violated by the so called "four-qubit the maximally entangled state |Gm" and it is also violated by four-qubit W state and a special family of states |Gab00. Moreover, a useful entanglement-nonlocality relationship for the family of states |Gab00is derived. Finally, we present a scheme of preparation of the state |Gmwith linear optics and cross-Kerr nonlinearities. |