Characterisation of magnetic resonance imaging (MRI) contrast agents using NMR relaxometry |
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| Authors: | Silvio Aime David Esteban-Gómez Carlos Platas-Iglesias |
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| Institution: | 1. Department of Molecular Biotechnologies and Health Sciences, Molecular Imaging Center, University of Torino, Torino, Italy;2. Departamento de Química, Facultade de Ciencias &3. Centro de Investigaciones Científicas Avanzadas (CICA), Universidade da Coru?a, A Coru?a, Spain |
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| Abstract: | ABSTRACTThis contribution describes the use of Fast Field-cycling relaxometry (FFC-NMR) for the characterisation of Gd(III)- and Mn(II)-based contrast agents for MRI. Through a series of selected examples, we analyse the role of different structural and dynamic parameters on 1H relaxivity and on the shape of the 1H Nuclear Magnetic Relaxation Dispersion (NMRD) profiles. The amplitude and shape of the profiles is affected by the number of water molecules coordinated to the metal ion, the water exchange rate, the rotational correlation time of the complex and the relaxation of the electron spin. As a result, 1H NMRD profiles represent a powerful tool for the understanding of the properties of MRI contrast agent candidates at the molecular level. |
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| Keywords: | Gadolinium NMR relaxometry MRI manganese |
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