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Multifractal analysis of the UV/VIS spectra of malignant ascites: Confirmation of the diagnostic validity of a clinically evaluated spectral analysis |
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| Authors: | Irini S Reljin Milka L Avramov-Ivi? Goran I Plavec Gordana M Bogdanovi? |
| Institution: | a Faculty of Electrical Engineering, University of Belgrade, Bulevar Kralja Aleksandra 73, 11000 Belgrade, Serbia b ICTM, Institute of Electrochemistry, University of Belgrade, Njegoševa 12/Karnegijeva 4, 11000 Belgrade, Serbia c Institute of Oncology Sremska Kamenica, Department for Gastroenterology, Institutski put 4, 21204 Sremska Kamenica, Serbia d Military-Medical Academy, Clinic for Lung Diseases and Tuberculosis, Crnotravska 17, 11000 Belgrade, Serbia e Faculty of Technology and Metallurgy, Department of Organic Chemistry, Karnegijeva 4, 11000 Belgrade, Serbia f Hemofarm Group, Pharmaceutical-Chemical Industry, 26300 Vršac, Serbia g Institute of Oncology Sremska Kamenica, Experimental Oncology Department, 21204 Sremska Kamenica, Institutski put 4, Serbia |
| Abstract: | Multifractal (MF) approach was applied for the analysis of ultraviolet/visible (UV/VIS) spectra as an independent confirmation of the diagnostic efficacy of UV/VIS spectral analysis of intraperitoneal fluids, ascites, taken from patients with a known clinical diagnosis. Recently, it was reported that from UV/VIS spectra differentiation of malignant from benign ascites is possible. Here, it was shown that by using MF analysis of UV/VIS spectra, the objective classification of UV/VIS spectra is possible. The applicability of UV/VIS analysis and MF classification of spectra were evaluated on N=68 cases, of which M=64 and B=4 were clinically confirmed as malignant and benign, respectively. The overall diagnostic efficacy was 89.71% when using on-line analysis of UV/VIS spectra (61 out of 68 samples were positively recognized: 58 malignant and 3 benign), and even 95.59% by using off-line MF classsification (65 out of 68 samples were classified correctly: 63 malignant and 2 benign). It can be inferred that UV/VIS spectral analysis of ascites, combined with MF analysis, could be suggested as a successful and safe screening method in the evaluation of intraperitoneal fluids. |
| Keywords: | Ascites Neoplasm Medical diagnosis UV/VIS spectroscopy Fractals Multifractal analysis |
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