脂肪酸环己胺合铂结构及抗肿瘤作用研究

用X射线衍射、红外光谱、差热分析等对合成的几种脂肪酸环己胺铂配合物的结构进行了研究.并选用黑色素瘤(LiBr),白血病细胞K₅₆₂,肝癌(7721)细胞做抗癌活性实验.结果发现:这几种脂肪酸环己胺铂配合物对肿瘤细胞的生长有抑制作用,并与浓度梯度和脂肪酸碳链的长度密切相关.肿瘤细胞对用不同强度磁场处理的药物有不同的敏感性.随着磁场强度的增加,抗癌效果明显增强.

PHYSIC-CHEMICAL CHARACTERISTICS OF THE PLATOSAMMINE FATTY ACIDS AND EFFECTS OF MAGNETIC FIELD ON TUMOR CELLS

This article presents the results of the research using the method of X ray diffraction,Forier transform infrared spectroscopy,differential thermal analysis and ultimate analysis to investigate the structures of the platosammine fatty acids.In the experiment,hematopoietic cell K 562 is elected the model of ectoderm;melenoma cell LiBr is elected the model of mesoderm;cancer cell of the liver 7721 is elected the model of ectoderm.The experimental results show that the inhibiting effect of the growth has a direct bearnig on the concentration and the length of hydrocarbon chain.The influence of magnetic field on the interaction between platosmmine fatty acid and tumor cells show that the same cell line has different sensibilities to treated platosammine fatty acid with magnetic field of different intenstiy,and the cell damaging effects are distinct increased with the heightened magnetic field intensity.The different cell line has different damage at the same magnetic field intensity.The combined treatment with magnetic field and platosammine fatty acid enhance greatly the damage of tumor cell.