| 激光扫描光学断层成像系统的设计与应用 |
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| 引用本文： | 薛成志,李亚敏,李贵叶,李颖超,胡学娟,陈玲玲.激光扫描光学断层成像系统的设计与应用[J].光子学报,2017,46(7). |
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| 作者姓名： | 薛成志 李亚敏 李贵叶 李颖超 胡学娟 陈玲玲 |
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| 作者单位： | 1. 深圳市激光工程重点实验室,广东深圳518060;深圳大学先进光学精密制造技术广东普通高校重点实验室,广东深圳518060;深圳大学电子科学与技术学院,广东深圳518060;2. 深圳市激光工程重点实验室,广东深圳518060;深圳大学先进光学精密制造技术广东普通高校重点实验室,广东深圳518060;深圳大学生命与海洋科学学院,广东深圳518060;3. 深圳市激光工程重点实验室,广东深圳518060;深圳大学先进光学精密制造技术广东普通高校重点实验室,广东深圳518060;深圳大学光电工程学院,广东深圳518060 |
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| 基金项目： | 国家自然基金，深圳市战略新兴产业发展专项资金，深圳市高端人才启动和深圳大学项目，深圳市科技计划基础研究项目(No.JCYJ20150625101401072)资助 The National Natural Science Foundation of China，Shenzhen Special Funding for the Development of Strategic Emerging Industries，Shenzhen High-end Talent and Shenzhen University Program，Shenzhen Science and Technology Plan Projects of Basic Research |
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| 摘 要： | 设计了基于LabVIEW控制的激光扫描光学断层成像系统,该系统以准直激光器为光源,高精度四维平移台为样本定位单元,光电倍增管为采集单元,实现了针对小鼠肺等小尺寸样本的三维成像.该系统空间分辨率优于20μm,成像视野大于1cm,通过对离体小鼠肺器官的自发荧光成像,展示了系统的操作流程、成像结果和初步生物应用,并探索了它对整个生物器官组织的成像能力.与传统生物医学光学成像方法相比,该方法具有光子收集效率高、成像样本尺寸大、系统操作简单等优点.
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| 关 键 词： | 激光扫描光学断层成像 荧光成像 介观尺寸 LabVIEW 生物器官 三维信息 成像系统 |
The Design of Scanning Laser Optical Tomography Imaging System and Its Applications |
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| XUE Cheng-zhi,LI Ya-min,LI Gui-ye,LI Ying-chao,HU Xue-juan,CHEN Ling-ling.The Design of Scanning Laser Optical Tomography Imaging System and Its Applications[J].Acta Photonica Sinica,2017,46(7). |
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| Authors: | XUE Cheng-zhi LI Ya-min LI Gui-ye LI Ying-chao HU Xue-juan CHEN Ling-ling |
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| Abstract: | This paper presented a self-designed scanning laser optical tomography mesoscopic imaging system based on LabVIEW and explored its capabilities to image intact biological organs or tissues.The system is consisted of an aligned laser,a four dimension translation stage,a scanning mirror and a photomultiplier tube.The spatial resolution of the system is better than 20 μtm with an imaging field of 1 cm.The system operation process and preliminary biomedical applications were demonstrated through the 3-D autofluorescence imaging of a mouse lung.Compared to the traditional biomedical optical imaging techniques,scanning laser optical tomography provides the advantages of high photon collection efficiency,large sample range and easy operation. |
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| Keywords: | Scanning laser optical tomography Fluorescence microscopy Mesoscopic size LabVIEW Biological organs Three-dimensional information Imaging systems |
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