针剂中异物的光电检测方法研究

针剂在实际生产过程中容易混入异物颗粒,异物颗粒影响人体健康,因此针剂在出厂前必须进行异物检测.本文提出了一种基于光阻法的针剂异物的检测方法,介绍了检测原理及其信号处理方法,单瓶静态实验表明,该方法与人工检测方法比较,符合率为96.30%.针对检测区域和测试时间过小所造成的漏检可能,提出了双光路检测方法,并通过实验论证了其可行性.

Study on the Complex Astigmatism in Nonplanar Cavity RLG and Design of the Diaphragm

Based on 4×4 matrix including meridian and latitude,the round-trip matrix of nonplanar cavity was established.According to the matrix,the q parameters matrix was calculated,the complex astigmatism in some nonplanar cavity ring laser gyro (RLG) was analyzed,and the spot radius of Gaussian beam at any location was obtained theoretically.Then the spot radii of the out-cavity Gaussian beam were measured by CCD,and the Gaussian beam waist was obtained by hyperbola fitting.The result was consistent with the theoretical one.According to spot radii,diaphragm radii and location,the diffraction loss was obtained.The designed diaphragm located at the Gaussian beam waist is circular,and the ratio of diaphragm radius to waist radius is about 2.The designed scheme guarantees the nonplanar cavity RLG works with single TEM00 mode.