| Optimal design and experimental measurement of the subharmonic characterizations of encapsulated microbubble |
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| 作者姓名： | ZONG Yujin WAN Mingxi WANG Suping CHEN Hong ZHANG Guolu |
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| 作者单位： | The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Department of Biomedical engineering, School of Life Science and Technology, Xi＇an Jiaotong University Xi＇an 710049 |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China (30270404)
High Technology Research and Development Program of China (863 Program, 2004AA218022). |
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| 摘 要： | Based on a theoretical motion equation of encapsulated microbubbles within an ultrasound field, the subharmonic characterizations of microbubbles are optimally designed and analyzed by a computer aided design system. The effects of size, shell elasticity and acoustic pressure on subharmonic response of microbubbles are calculated theoretically to obtain the optimal parameters for nondestructive subharmonic imaging. In addition, microbubbles with different shell elasticity are prepared, and their subharmonic responses are measured in vitro. The results of theoretical calculation and acoustic measurement show that good subharmonic enhancement can be obtained by using the encapsulated microbubbles with the mean size of 3 μm, which were prepared from the surfactant solution with the proper ratio of shell material. It is also shown that the best operating acoustic pressure is 200 to 400 kPa for nondestructive subharmonic imaging based on such kind of microbubbles.
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| 关 键 词： | 最优化设计 实验测量 分谐波性 理论运动方程 超声场 声学工程 |
| 收稿时间： | 2005-06-07 |
| 修稿时间： | 2005-06-072005-09-09 |
Optimal design and experimental measurement of the subharmonic characterizations of encapsulated microbubble |
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| Authors: | ZONG Yujin WAN Mingxi WANG Suping CHEN Hong ZHANG Guolu |
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